KinaseSTAR JNK Activity Screening Kit

Hazard statements (CLP)

H301, H302+H312, H303, H314, H315, H316, H318, H319, H320, H332, H335, H402, H412

Code

Statements

H301

Toxic if swallowed

SECTION 2: Hazards identification

NFPA Rating Component Description Volume Safety Information Kinase Extraction Buffer Proprietary Buffer (contains (contains Triton X-100, EDTA, DTT, PMSF, 80 ml See below sodium pyrophosphate, Na3VO4) c-Jun (1-79) Fusion Protein Beads 50% slurry (contains Triton X-100, EDTA, glycerol, Na3VO4, sodium 800 µl See below pyrophosphate) Kinase Assay Buffer Proprietary Buffer (contains DTT, Na3VO4) 25 ml See below ATP (10 mM) Aqueous solution 50 µl No hazards Phospho-c-Jun Specific Antibody Produced from rabbit serum (contains 50% glycerol) 50 µl See below Triton X-100: Emergency Overview

2.3 Other hazards

Irritant, Harmful by ingestion Irritant Target organ effect, Toxic by ingestion, Irritant Target Organs: Central nervous system Target organ effect, Toxic by ingestion, Corrosive Target Organs: Nerves, Heart, Blood, Eyes Irritant Harmful by ingestion, Harmful by inhalation, Harmful by skin absorption Target Organ Effect Target Organs: Kidney

2.1 Classification of the substance or mixture

Serious eye damage (Category 1) Skin irritation (Category 3) Acute aquatic toxicity (Category 3) Chronic aquatic toxicity (Category 3) Acute toxicity, Oral (Category 5) Eye irritation (Category 2A) Acute aquatic toxicity (Category 3) Acute toxicity, Oral (Category 5) Skin irritation (Category 2) Eye irritation (Category 2A) Acute toxicity, Oral (Category 3) Skin corrosion (Category 1B) Serious eye damage (Category 1) Skin irritation (Category 2) Eye irritation (Category 2A) Specific target organ toxicity –single exposure (Category 3) Acute toxicity, Oral (Category 4) Acute toxicity, Inhalation (Category 4) Acute toxicity, Dermal (Category 4) Acute aquatic toxicity (Category 3) Skin irritation (Category 3) Eye irritation (Category 2B)

Signal word

Danger Warning Warning Danger Warning Warning Warning

Hazard statements

H316 Causes mild skin irritation. H318 Causes serious eye damage. H412 Harmful to aquatic life with long lasting effects. H303 May be harmful if swallowed. H319 Causes serious eye irritation. H402 Harmful to aquatic life. H303 May be harmful if swallowed H315 Causes skin irritation H319 Causes serious eye irritation H301 Toxic if swallowed. H314 Causes severe skin burns and eye damage. H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. H302+H312 Harmful if swallowed or in contact with skin. H332 Harmful if inhaled. H402 Harmful to aquatic life. H316 Causes mild skin irritation. H320 Causes eye irritation.

Precautionary statements

P261 Avoid breathing dust/fumes/gas/mist/vapors/spray P264 Wash hands thoroughly after handling. P273 Avoid release to the environment. P280 Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P261 Avoid breathing dust/fumes/gas/mist/vapors/spray P264 Wash skin thoroughly after handling. P273 Avoid release to the environment. P280 Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312 Call a POISON CENTER or doctor/physician if you feel unwell. P337+P313 If eye irritation persists: Get medical advice/attention. P305+P351+P338 IF IN EYES Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280 Wear protective gloves/protective clothing/eye protection/face protection P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P310 Immediately call a POISON CENTER or doctor/physician. P261 Avoid breathing dust/fumes/gas/mist/vapors/spray P280 Wear protective gloves/protective clothing/eye protection/face protection. P302+P352 IF ON SKIN: Wash with plenty of soap and water. P304+P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P332+P313 If skin irritation occurs: Get medical advice/attention. P337+P313 If eye irritation persists: Get medical advice/attention. P261 Avoid breathing dust/fume/gas/mist/vapors/spray P264 Wash hands thoroughly after handling. P280 Wear protective gloves/protective clothing. P301+P312 IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P330 Rinse mouth. P305+P351+P338 IF IN EYES Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Health hazards

2 Flammability: 1 2 Fire: 1 Reactivity Hazard: 0 2 Flammability: 0 2 Fire: 0 Reactivity Hazard: 0 2 Flammability: 0 2 Fire: 0 Reactivity Hazard: 0 3 Flammability: 0 3 Fire: 0 Reactivity Hazard: 1 2 Flammability: 0 2 Fire: 0 Reactivity Hazard: 0 2 Flammability: 0 2 Fire: 0 Reactivity Hazard: 0 1 Flammability: 1 1 Fire: 1 Reactivity Hazard: 0

Physical hazards

0 0 0 1 0 0 0

Potential health effects

Inhalation: May be harmful if inhaled. Causes respiratory tract irritation. Skin: Harmful if absorbed through skin. Causes skin irritation. Eyes: Causes eye irritation. Ingestion: Harmful if swallowed. EDTA: Emergency Overview Inhalation: May be harmful if inhaled. Causes respiratory tract irritation. Skin: May be harmful if absorbed through skin. Causes skin irritation. Eyes: Causes eye irritation. Ingestion: May be harmful if swallowed. DTT: Emergency Overview Inhalation: May be harmful if inhaled. Causes respiratory tract irritation. Skin: May be harmful if absorbed through skin. Causes skin irritation. Eyes: Causes eye irritation. Ingestion: Toxic if swallowed. PMSF: Emergency Overview Inhalation: May be harmful if inhaled. Material is extremely destructive to the tissue of the mucous membranes and upper respiratory tract. Skin: Causes skin irritation. Eyes: Causes eye irritation. Ingestion: May be harmful if swallowed. Sodium pyrophosphate: Emergency Overview Inhalation: May be harmful if inhaled. Causes respiratory tract irritation. Skin: May be harmful if absorbed through skin. Causes skin irritation. Eyes: Causes eye irritation. Ingestion: May be harmful if swallowed. Sodium orthovanadate: Emergency Overview Inhalation: Harmful if inhaled. May cause respiratory tract irritation. Skin: Harmful if absorbed through skin. May cause skin irritation. Eyes: May cause eye irritation. Ingestion: Harmful if swallowed. Glycerol: Emergency Overview Inhalation: May be harmful if inhaled. May cause respiratory tract irritation. Skin: May be harmful if absorbed through skin. May cause skin irritation. Eyes: May cause eye irritation. Ingestion: May be harmful if swallowed.