FLICE/Caspase-8 Colorimetric Assay Kit

Hazard statements (CLP)

H227, H303, H315, H317, H319, H400, H410

Code

Statements

H227

Combustible liquid

SECTION 2: Hazards identification

OSHA Hazards Component Description K113-25 K113-100 K113-200 K113-400 Safety Information Cell Lysis Buffer Proprietary Buffer (contains 25 ml 100 ml See below Tergitol) 2X Reaction Buffer Liquid ( contains Glycerol) 2 ml 4 x 2 ml 16 ml 32 ml See below IETD-pNA (4 mM) Liquid (contains DMSO) 125 µl 0.5 ml 2 x 0.5 ml 2 x 1 ml See below DTT (1 M) Liquid 100 µl 0.4 ml See below Dilution Buffer Proprietary Buffer (contains 25 ml 100 200 400 See below Tergitol & Glycerol) Tergitol: Emergency Overview

2.1 Classification of the substance or mixture

Skin irritation (Category 2), H315 Skin sensitization (Sub-category 1A), H317 Short-term (acute) aquatic hazard (Category 1), H400 Long-term (chronic) aquatic hazard (Category 1), H410 Flammable liquids (Category 4) Acute toxicity, Oral (Category 5) Skin irritation (Category 2) Eye irritation (Category 2A) Not available

Signal word

Warning Warning Warning Warning

Hazard statements

H315 Causes skin irritation. H317 May cause an allergic skin reaction. H410 Very toxic to aquatic life with long lasting effects. H227 Combustible liquid H303 May be harmful if swallowed H315 Causes skin irritation H319 Causes serious eye irritation Not available

Precautionary statements

P261 Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray P264 Wash skin thoroughly after handling. P272 Contaminated work clothing must not be allowed out of the workplace. P273 Avoid release to the environment. P280 Wear protective gloves. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P333 + P313 If skin irritation or rash occurs: Get medical advice/ attention. P362 Take off contaminated clothing and wash before reuse. P391 Collect spillage. P501 Dispose of contents/ container to an approved waste disposalplant none P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. none

Health hazards

0 Flammability: 0 0 Fire: 0 Reactivity hazard: 0 0 Flammability: 2 0 Fire: 2 Reactivity Hazard: 0 2 Flammability: 0 2 Fire: 0 Reactivity Hazard: 0 1 0 Flammability: 1 1 Fire: 0 Reactivity Hazard: 0

Physical hazards

0 0 0 0

Potential health effects

Inhalation: May be harmful if inhaled. Material is irritating to the tissue of the mucous membranes and upper respiratory tract.Harmful; if inhaled. May cause allergy or asthma symptoms or breathing difficulties. Skin: May be harmful if absorbed through skin. May cause an allergic skin reaction. DMSO: Emergency Overview Inhalation: May be harmful if inhaled. May cause respiratory tract irritation. Skin: May be harmful if absorbed through skin. May cause skin irritation. Eyes: May cause eye irritation. Ingestion: May be harmful if swallowed. Inhalation: May be harmful if inhaled. Causes respiratory tract irritation. Skin: May be harmful if absorbed through skin. Causes skin irritation. Eyes: Causes eye irritation. Ingestion: Toxic if swallowed. Eyes: Causes eye irritation. Ingestion: Toxic if swallowed. Glycerol: Emergency Overview Inhalation: Low hazard for usual industrial handling. Inhalation of a mist of this material may cause respiratory tract irritation. Skin: May cause skin irritation. Low hazard for usual industrial handling Eyes: May cause eye irritation. Ingestion: Ingestion of large amounts may cause gastrointestinal irritation. Low hazard for usual industrial handling. May cause headache.

2.3 Other hazards

Combustible Liquid, Target Organ Effect Target Organs: Eyes, Skin Target Organ Effect, Toxic by ingestion, Irritant Target Organs: Central nervous system Not available Target Organs: Eyes, Skin

Medical Conditions Generally Aggravated by Exposure

Avoid contact w/DMSO solutions containing toxic materials or materials with unknown toxicological properties. DMSO is readily absorbed through skin and may carry such materials into the body. DTT: Emergency Overview