EZSOLUTION AZD-9291 (OSIMERTINIB)

BioVision, Inc

Revision date : 2019-05-03

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GHS07
Health risk rating 3
Safety risk rating 1
Environmental risk rating 1

Note: Ingredients listed on restricted chemical lists

EC/CAS

67-68-5

Name of the chemical

dimethyl sulphoxide

Concentration

N/A

EC/CAS

200-664-3

Name of the chemical

Dimethyl sulfoxide (INN)

Concentration

N/A

General Information

Revision date

2019-05-03

Product name

EZSOLUTION AZD-9291 (OSIMERTINIB)

1.2.1 Relevant identified uses

For laboratory research purposes Not for drug or household use

Manufacturer Name

BioVision, Inc

Emergency telephone

OTHER CALLS

Icons in SDS

Company Information

company name

BioVision, Inc

GHS Information

Signal word

Warning

Hazard Codes

Hazard statements (CLP)

H227, H302, H315, H319, H335

Hazard statements

Code

Statements

H227

Combustible liquid

Section 2

SECTION 2: Hazards identification

OSHA Hazards Product Name/Chemical Name Description Volume Safety Information EZSOLUTION™ AZD-9291 In DMSO B2490-5: 5 mg See below (OSIMERTINIB) EZSOLUTION™ AZD-9291 (OSIMERTINIB):

2.1 Classification of the substance or mixture

Acute toxicity, Oral (Category 4) Skin irritation (Category 2) Eye irritation (Category 2A) Specific target organ toxicity - single exposure (Category 3) Flammable liquids (Category 4)

Signal word

Warning Warning

Hazard statements

H302 Harmful if swallowed. H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. H227 Combustible liquid

Precautionary statements

P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/ eye protection/ face protection. P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. none

Health hazards

0 Flammability: 0 0 Fire: 0 Reactivity Hazard: 0 0 Flammability: 2 0 Fire: 2 Reactivity Hazard: 0

Physical hazards

0 0

Potential health effects

Inhalation: May be harmful if inhaled. May cause respiratory tract irritation. Skin: May be harmful if absorbed through skin. May cause skin irritation. Eyes: May cause eye irritation. Ingestion: May be harmful if swallowed. DMSO: Emergency Overview Inhalation: May be harmful if inhaled. May cause respiratory tract irritation. Skin: May be harmful if absorbed through skin. May cause skin irritation. Eyes: May cause eye irritation. Ingestion: May be harmful if swallowed.

2.3 Other hazards

Combustible liquid, Target organ effect Target Organs: Eyes, Skin

Hazard pictograms

none

Medical Conditions Generally Aggravated by Exposure

Avoid contact w/DMSO solutions containing toxic materials or materials with unknown toxicological properties. DMSO is readily absorbed through skin and may carry such materials into the body.

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