DiscoveryPak HDAC Inhibitor Set II

Hazard statements (CLP)

H301+H331, H302+H312+H332, H315, H317, H319, H335, H341, H360

Code

Statements

H301+H331

Toxic if swallowed or if inhaled

SECTION 2: Hazards identification

NFPA Rating Component Description Amount Safety Information CI-994 Lyophilized 1o mg See below Panobinostat Lyophilized 1 mg See below SAHA Lyophilized 1 mg See below SBHA Lyophilized 50 mg No hazards Scriptaid Lyophilized 1 mg No hazards Trichostatin A Lyophilized 1 mg See below Tubacin Lyophilized 250 ug See below CI-994: Emergency Overview

2.3 Other hazards

Target organ effect Target Organs: Eyes, Skin, respiratory system Target organ effect Target Organs: Eyes, Skin, reproductive system Target Organs: Target organ effect Target Organs: Eyes, Skin, respiratory system

2.1 Classification of the substance or mixture

Acute toxicity, Oral (Category 2) Skin irritation (Category 2) Eye irritation (Category 2A) Specific target organ toxicity - single exposure (Category 3), Respiratory system Acute toxicity, Oral (Category 3), Inhalation (Category 3) Skin corrosion/ irritation (Category 2) Eye damage/irritation (Category 1) Toxic to reproduction (Category 1B) Specific target organ toxicity - repeated exposure (Category 2) Germ cell mutagenicity (Category 2) Reproductive toxicity (Category 1A) Acute toxicity, Oral (Category 4) Acute toxicity, Inhalation (Category 4) Acute toxicity, Dermal (Category 4) Skin irritation (Category 2) Eye irritation (Category 2A) Skin sensitisation (Category 1) Specific target organ toxicity - single exposure (Category 3), Respiratory system,

Signal word

Warning Danger Danger Warning

Hazard statements

H319 Causes serious eye irritation H301 + 331 Toxicl if swallowed or inhaled H315 Causes skin irritation. H319 Causes serious eye damage. H335 May cause respiratory irritation. H341 Suspected of causing genetic defects. H360 May damage fertility or the unborn child. H302 + H312 + H332 Harmful if swallowed, in contact with skin or if inhaled H315 Causes skin irritation. H317 May cause an allergic skin reaction. H319 Causes serious eye irritation. H335 May cause respiratory irritation.

Precautionary statements

P264 Wash skin thoroughly after handling P280 Wear protective gloves/ eye protection/ face protection. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337 + P313 If eye irritation persists: Get medical advice/ attention. P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/ eye protection/ face protection. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician. 2 + P352 IF ON SKIN: Wash with plenty of soap and water. 4 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. 5 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312 Call a POISON CENTER or doctor/ physician if you feel unwell. P321 Specific treatment (see supplemental first aid instructions on this label). P330 Rinse mouth. P332 + P313 If skin irritation occurs: Get medical advice/ attention. P337 + P313 If eye irritation persists: Get medical advice/ attention. P362 Take off contaminated clothing and wash before reuse. P403 + P233 Store in a well-ventilated place. Keep container tightly closed. P201 Obtain special instructions before use P202 Do not handle until all safety precautions have been read and understood. P281 Use personal protective equipment as required. P308 + P313 IF exposed or concerned: Get medical advice/ attention. P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant. P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P272 Contaminated work clothing should not be allowed out of the workplace. P280 Wear eye protection/ face protection/protective gloves/ protective clothing. P301 + P312 + P330 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell. Rinse mouth. P302 + P352 + P312 IF ON SKIN: Wash with plenty of soap and water. Call a POISON CENTER or doctor/ physician if you feel unwell. P304 + P340 + P312 IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER or doctor/ physician if you feel unwell. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P333 + P313 If skin irritation or rash occurs: Get medical advice/ attention. P337 + P313 If eye irritation persists: Get medical advice/ attention. P362 Take off contaminated clothing and wash before reuse. P403 + P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant.

Health hazards

1 Flammability: 0 1 Fire: 0 Reactivity Hazard: 0 4 Flammability: 0 3 Fire: 0 Reactivity Hazard: 0 0 Flammability: 0 0 Fire: 0 Reactivity Hazard: 0 2 Flammability: 0 2 Fire: 0 Reactivity Hazard: 0

Physical hazards

0 0 0 0

Potential health effects

Eyes: Causes serious eye irritation. Panobinostat: Emergency Overview Inhalation: May be harmful if inhaled. May cause respiratory tract irritation. Skin: May be harmful if absorbed through skin. May cause skin irritation. Eyes: May cause eye irritation. Ingestion: May be harmful if swallowed. SAHA: Emergency Overview Inhalation: May be harmful if inhaled. May cause respiratory tract irritation. Skin: May be harmful if absorbed through skin. May cause skin irritation. Eyes: May cause eye irritation. Ingestion: May be harmful if swallowed. Trichostatin A: Emergency Overview Inhalation: May be harmful if inhaled. May cause respiratory tract irritation. Skin: May be harmful if absorbed through skin. May cause skin irritation. Eyes: May cause eye irritation. Ingestion: May be harmful if swallowed.