Avapritinib

Hazard statements (CLP)

H315, H317, H318, H334, H335, H341, H361, H370, H413

Code

Statements

H315

Causes skin irritation

SECTION 2: Hazards identification

Product Name/Chemical Name CAS Number MW Chemical Formula Concentration Avapritinib 1703793-34-3 498.6 C26H27FN10 100% Avapritinib: Emergency Overview

2.3 Other hazards

Target organ effect, Harmful by ingestion, Irritant, Carcinogen Target Organs: Heart, bone marrow, blood, liver

2.1 Classification of the substance or mixture

Acute toxicity, Oral (Category 4) Carcinogenicity (Category 1B)

Signal word

Danger

Hazard statements

H315: Causes skin irritation. H317: May cause an allergic skin reaction. H318: Causes serious eye damage. H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled. H335: May cause respiratory irritation. H341: Suspected of causing genetic defects. H361: Suspected of damaging fertility or the unborn child. H370: Causes damage to organs. H413: May cause long lasting harmful effects to aquatic life.

Precautionary statements

P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P260: Do not breathe {dust/fume/gas/mist/vapors/spray}. P264: Wash {hands} thoroughly after handling. P272: Contaminated work clothing should not be allowed out of the workplace. P273: Avoid release to the environment. P280: Wear {protective gloves/protective clothing/eye protection/face protection}. P285: In case of inadequate ventilation wear respiratory protection.

Health hazards

2 Flammability: 0 2 Fire: 0 Reactivity Hazard: 0

Physical hazards

0

Potential health effects

Inhalation: May be harmful if inhaled. May cause respiratory tract irritation. Skin: Harmful if absorbed through skin. Causes skin irritation. Eyes: Causes eye irritation. Ingestion: Harmful if swallowed.