Hind III Lambda Digest DNA Standard

Non Hazardous Components

Proprietary Balance Section 4: First-aid measures HRLS00987 - 2X Restriction Buffer Description of first aid measures Inhalation Remove to fresh air. Eye contact Rinse thoroughly with plenty of water for at least 15 minutes, lifting lower and upper eyelids. Consult a physician. Skin contact Wash skin with soap and water. Ingestion Rinse mouth. Most important symptoms and effects, both acute and delayed Symptoms Indication of any immediate medical attention and special treatment needed Note to physicians Treat symptomatically. Section 5: Fire-fighting measures Suitable Extinguishing Media Use extinguishing measures that are appropriate to local circumstances and the surrounding environment. Large Fire CAUTION: Use of water spray when fighting fire may be inefficient. Unsuitable extinguishing media Do not scatter spilled material with high pressure water streams. Specific hazards arising from the chemical Specific hazards arising from the chemical Special protective actions for fire-fighters Special protective equipment and Firefighters should wear self-contained breathing apparatus and full firefighting turnout gear. precautions for fire-fighters Section 6: Accidental release measures Personal precautions, protective equipment and emergency procedures Personal precautions Ensure adequate ventilation. For emergency responders Use personal protection recommended in Section 8. Environmental precautions See Section 12 for additional Ecological Information. Methods and material for containment and cleaning up Methods for containment Prevent further leakage or spillage if safe to do so. Methods for cleaning up Pick up and transfer to properly labeled containers. Precautions to prevent secondary hazards HRLS00987 - 2X Restriction Buffer Prevention of secondary hazards Clean contaminated objects and areas thoroughly observing environmental regulations. Section 7: Handling and storage Precautions for safe handling Advice on safe handling Handle in accordance with good industrial hygiene and safety practice. Conditions for safe storage, including any incompatibilities Proprietary Balance _____________________________________________________________________________________________ Page 50 / 57 HRLS00990 - Sample Loading Dye Section 4: First-aid measures Description of first aid measures Inhalation Remove to fresh air. Eye contact Rinse thoroughly with plenty of water for at least 15 minutes, lifting lower and upper eyelids. Consult a physician. Skin contact Wash skin with soap and water. Ingestion Rinse mouth. Most important symptoms and effects, both acute and delayed Symptoms Indication of any immediate medical attention and special treatment needed Note to physicians Treat symptomatically. Section 5: Fire-fighting measures Suitable Extinguishing Media Use extinguishing measures that are appropriate to local circumstances and the surrounding environment. Large Fire CAUTION: Use of water spray when fighting fire may be inefficient. Unsuitable extinguishing media Do not scatter spilled material with high pressure water streams. Specific hazards arising from the chemical Specific hazards arising from the chemical Special protective actions for fire-fighters Special protective equipment and Firefighters should wear self-contained breathing apparatus and full firefighting turnout gear. precautions for fire-fighters Section 6: Accidental release measures Personal precautions, protective equipment and emergency procedures Personal precautions Ensure adequate ventilation. For emergency responders Use personal protection recommended in Section 8. Environmental precautions See Section 12 for additional Ecological Information. Methods and material for containment and cleaning up Methods for containment Prevent further leakage or spillage if safe to do so. Methods for cleaning up Pick up and transfer to properly labeled containers. HRLS00990 - Sample Loading Dye Precautions to prevent secondary hazards Prevention of secondary hazards Clean contaminated objects and areas thoroughly observing environmental regulations. Section 7: Handling and storage Precautions for safe handling Advice on safe handling Handle in accordance with good industrial hygiene and safety practice. Conditions for safe storage, including any incompatibilities

Storage

Conditions Store according to product and label instructions. Incompatible materials None known based on information supplied. Section 8: Exposure controls/personal protection Control parameters Exposure Limits This product, as supplied, does not contain any hazardous materials with occupational exposure limits established by the region specific regulatory bodies. Biological occupational exposure This product, as supplied, does not contain any hazardous materials with biological limits limits established by the region specific regulatory bodies. Appropriate engineering controls Engineering controls Showers Eyewash stations Ventilation systems. Individual protection measures, such as personal protective equipment Eye/face protection No special protective equipment required. Hand protection No special protective equipment required. Skin and body protection No special protective equipment required. Respiratory protection No protective equipment is needed under normal use conditions. If exposure limits are exceeded or irritation is experienced, ventilation and evacuation may be required. Environmental exposure controls Section 9: Physical and chemical properties Information on basic physical and chemical properties Physical state Liquid Appearance aqueous solution Colour colourless Odour Odourless. Odour threshold Property Values Conditions Store according to product and label instructions. Incompatible materials None known based on information supplied. Section 8: Exposure controls/personal protection Control parameters Exposure Limits Australia ACGIH TLV United Kingdom 1,2,3-Propanetriol TWA: 10 mg/m3 - TWA: 10 mg/m3 56-81-5 STEL: 30 mg/m3 Biological occupational exposure This product, as supplied, does not contain any hazardous materials with biological limits limits established by the region specific regulatory bodies. Appropriate engineering controls Engineering controls Showers Eyewash stations Ventilation systems. Individual protection measures, such as personal protective equipment Eye/face protection No special protective equipment required. Hand protection No special protective equipment required. Skin and body protection No special protective equipment required. Respiratory protection No protective equipment is needed under normal use conditions. If exposure limits are exceeded or irritation is experienced, ventilation and evacuation may be required. Environmental exposure controls Section 9: Physical and chemical properties Information on basic physical and chemical properties Physical state Liquid Appearance aqueous solution Colour blue Odour Odourless. Odour threshold No information available HRLS00990 - Sample Loading Dye Property Values

Remarks

Method pH None known Melting point / freezing point 0 °C HRLS00987 - 2X Restriction Buffer Boiling point / boiling range 100 °C Flash point No data available None known Evaporation rate No data available None known Flammability (solid, gas) No data available None known Flammability Limit in Air None known Upper flammability or explosive No data available limits Lower flammability or explosive No data available limits Vapour pressure No data available None known Vapour density No data available None known Relative density No data available None known Water solubility No data available Miscible in water Solubility(ies) No data available None known Partition coefficient No data available None known Autoignition temperature No data available None known Decomposition temperature None known Kinematic viscosity No data available None known Dynamic viscosity No data available None known Explosive properties Chemical stability Stability Stable under normal conditions. Explosion data Sensitivity to mechanical impact None. Sensitivity to static discharge None. Possibility of hazardous reactions None under normal processing. Conditions to avoid None known based on information supplied. Incompatible materials None known based on information supplied. Hazardous decomposition products Hazardous decomposition products None known based on information supplied. Method pH None known Melting point / freezing point No data available None known Boiling point / boiling range > 100 °C Flash point No data available None known Evaporation rate No data available None known Flammability (solid, gas) No data available None known Flammability Limit in Air None known Upper flammability or explosive No data available limits Lower flammability or explosive No data available limits Vapour pressure No data available None known Vapour density No data available None known Relative density No data available None known Water solubility No data available Miscible in water Solubility(ies) No data available None known Partition coefficient No data available None known Autoignition temperature No data available None known Decomposition temperature None known Kinematic viscosity No data available None known Dynamic viscosity No data available None known Explosive properties Chemical stability Stability Stable under normal conditions. Explosion data Sensitivity to mechanical impact None. Sensitivity to static discharge None. Possibility of hazardous reactions None under normal processing. Conditions to avoid None known based on information supplied. Incompatible materials None known based on information supplied. Hazardous decomposition products HRLS00990 - Sample Loading Dye Hazardous decomposition products None known based on information supplied.

TOXICOLOGICAL INFORMATION

HRLS00987 - 2X Restriction Buffer Acute toxicity Information on likely routes of exposure Product Information Inhalation Specific test data for the substance or mixture is not available. Eye contact Specific test data for the substance or mixture is not available. Skin contact Specific test data for the substance or mixture is not available. Ingestion Specific test data for the substance or mixture is not available. Symptoms Acute toxicity Numerical measures of toxicity Delayed and immediate effects as well as chronic effects from short and long-term exposure Skin corrosion/irritation Data used to identify the health Refer to Section 16 for Key literature references and sources for data used to compile the effects SDS. Acute toxicity Information on likely routes of exposure Product Information Inhalation Specific test data for the substance or mixture is not available. Eye contact Specific test data for the substance or mixture is not available. Skin contact Specific test data for the substance or mixture is not available. Ingestion Specific test data for the substance or mixture is not available. Symptoms Oral LD50 Dermal LD50 Inhalation LC50 1,2,3-Propanetriol = 12600 mg/kg ( Rat ) > 10 g/kg ( Rabbit ) > 2.75 mg/L ( Rat ) 4 h Delayed and immediate effects as well as chronic effects from short and long-term exposure Skin corrosion/irritation Data used to identify the health Refer to Section 16 for Key literature references and sources for data used to compile the effects SDS. HRLS00990 - Sample Loading Dye

ECOLOGICAL INFORMATION

Ecotoxicity Aquatic ecotoxicity Unknown aquatic toxicity 0 % of the mixture consists of component(s) of unknown hazards to the aquatic environment. HRLS00987 - 2X Restriction Buffer Bioaccumulative potential Bioaccumulation There is no data for this product. Mobility in soil Mobility Section 13: Disposal considerations Waste treatment methods Waste from residues/unused Not applicable. products Not Hazardous. Dispose of in accordance with local regulations. Dispose of waste in accordance with environmental legislation. Contaminated packaging Not applicable. Not Hazardous. Section 14: Transport information IATA Not regulated IMDG Not regulated Transport in bulk according to Annex II of MARPOL and the IBC Code Special precautions for user Please refer to the applicable dangerous goods regulations for additional information Section 15: Regulatory information Safety, health and environmental regulations/legislation specific for the substance or mixture National regulations EPA New Zealand HSNO approval To be determined code or group standard National regulations There are no applicable tolerable exposure limits or environmental exposure limits according to the EPA Controls for Hazardous Substances Certified handlers, tracking and Certified handlers are required for some substances. This includes substances requiring a controlled substance license controlled substance license, and most explosives, vertebrates toxic agents, and certain requirements fumigants. Acutely toxic substances which are a Category 1 or 2, such as pesticides also require Certified handlers. Please check the Health and Safety at Work Act 2015 for further HRLS00987 - 2X Restriction Buffer information Tracking is required for some highly hazardous substances. These substances need to be under the control of an appropriately trained person or appropriately secured. Please check the Health and Safety at Work Act 2015 for further information Controlled substance licenses are required to possess certain explosives, vertebrate toxic agents and fumigants. See Part 7 of the Health and Safety at Work Regulation 2017 for more information International Regulations The Montreal Protocol on Substances that Deplete the Ozone Layer Not applicable The Stockholm Convention on Persistent Organic Pollutants Not applicable The Rotterdam Convention Not applicable International Inventories NZIoC Contact supplier for inventory compliance status. TSCA Contact supplier for inventory compliance status. DSL/NDSL Contact supplier for inventory compliance status. EINECS/ELINCS Contact supplier for inventory compliance status. ENCS Contact supplier for inventory compliance status. IECSC Contact supplier for inventory compliance status. KECL Contact supplier for inventory compliance status. PICCS Contact supplier for inventory compliance status. AICS Contact supplier for inventory compliance status. Legend: NZIoC - New Zealand Inventory of Chemicals TSCA - United States Toxic Substances Control Act Section 8(b) Inventory DSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances List EINECS/ELINCS - European Inventory of Existing Chemical Substances/European List of Notified Chemical Substances ENCS - Japan Existing and New Chemical Substances IECSC - China Inventory of Existing Chemical Substances KECL - Korean Existing and Evaluated Chemical Substances PICCS - Philippines Inventory of Chemicals and Chemical Substances AICS - Australian Inventory of Chemical Substances Ecotoxicity Aquatic ecotoxicity Unknown aquatic toxicity 0 % of the mixture consists of component(s) of unknown hazards to the aquatic environment. Algae/aquatic plants Fish Crustacea 1,2,3-Propanetriol - LC50: 51 - 57mL/L (96h, - Oncorhynchus mykiss) Terrestrial ecotoxicty There is no data for this product. Persistence and degradability Partition coefficient 1,2,3-Propanetriol -1.75 Mobility in soil Mobility Section 13: Disposal considerations Waste treatment methods Waste from residues/unused Not applicable. products Not Hazardous. Dispose of in accordance with local regulations. Dispose of waste in accordance with environmental legislation. Contaminated packaging Not applicable. Not Hazardous. Section 14: Transport information IATA Not regulated IMDG Not regulated Transport in bulk according to Annex II of MARPOL and the IBC Code Section 15: Regulatory information Safety, health and environmental regulations/legislation specific for the substance or mixture EPA New Zealand HSNO approval To be determined code or group standard National regulations There are no applicable tolerable exposure limits or environmental exposure limits according to the EPA Controls for Hazardous Substances Certified handlers, tracking and Certified handlers are required for some substances. This includes substances requiring a controlled substance license controlled substance license, and most explosives, vertebrates toxic agents, and certain requirements fumigants. Acutely toxic substances which are a Category 1 or 2, such as pesticides also require Certified handlers. Please check the Health and Safety at Work Act 2015 for further information Tracking is required for some highly hazardous substances. These substances need to be under the control of an appropriately trained person or appropriately secured. Please check the Health and Safety at Work Act 2015 for further information Controlled substance licenses are required to possess certain explosives, vertebrate toxic agents and fumigants. See Part 7 of the Health and Safety at Work Regulation 2017 for more information International Regulations The Montreal Protocol on Substances that Deplete the Ozone Layer Not applicable The Stockholm Convention on Persistent Organic Pollutants Not applicable The Rotterdam Convention Not applicable International Inventories NZIoC Contact supplier for inventory compliance status. TSCA Contact supplier for inventory compliance status. DSL/NDSL Contact supplier for inventory compliance status. EINECS/ELINCS Contact supplier for inventory compliance status. ENCS Contact supplier for inventory compliance status. IECSC Contact supplier for inventory compliance status. KECL Contact supplier for inventory compliance status. PICCS Contact supplier for inventory compliance status. AICS Contact supplier for inventory compliance status. Legend: NZIoC - New Zealand Inventory of Chemicals TSCA - United States Toxic Substances Control Act Section 8(b) Inventory DSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances List EINECS/ELINCS - European Inventory of Existing Chemical Substances/European List of Notified Chemical Substances ENCS - Japan Existing and New Chemical Substances IECSC - China Inventory of Existing Chemical Substances KECL - Korean Existing and Evaluated Chemical Substances PICCS - Philippines Inventory of Chemicals and Chemical Substances AICS - Australian Inventory of Chemical Substances

Further information

Revision 30-Aug-2022 Revision Note Significant changes throughout SDS. Review all sections. Key or legend to abbreviations and acronyms used in the safety data sheet Legend Section 8: EXPOSURE CONTROLS/PERSONAL PROTECTION TWA TWA (time-weighted average) STEL STEL (Short Term Exposure Limit) Ceiling Maximum limit value * Skin designation C Carcinogen Key literature references and sources for data used to compile the SDS Agency for Toxic Substances and Disease Registry (ATSDR) U.S. Environmental Protection Agency ChemView Database European Food Safety Authority (EFSA) EPA (Environmental Protection Agency) Acute Exposure Guideline Level(s) (AEGL(s)) U.S. Environmental Protection Agency Federal Insecticide, Fungicide, and Rodenticide Act U.S. Environmental Protection Agency High Production Volume Chemicals Food Research Journal Revision 30-Aug-2022 Revision Note Reformatted and updated existing information. Key or legend to abbreviations and acronyms used in the safety data sheet Legend Section 8: EXPOSURE CONTROLS/PERSONAL PROTECTION TWA TWA (time-weighted average) STEL STEL (Short Term Exposure Limit) Ceiling Maximum limit value * Skin designation C Carcinogen Key literature references and sources for data used to compile the SDS HRLS00990 - Sample Loading Dye Agency for Toxic Substances and Disease Registry (ATSDR) U.S. Environmental Protection Agency ChemView Database European Food Safety Authority (EFSA) EPA (Environmental Protection Agency) Acute Exposure Guideline Level(s) (AEGL(s)) U.S. Environmental Protection Agency Federal Insecticide, Fungicide, and Rodenticide Act U.S. Environmental Protection Agency High Production Volume Chemicals Food Research Journal

Hazardous Ingredients

Database International Uniform Chemical Information Database (IUCLID) National Institute of Technology and Evaluation (NITE) Australia National Industrial Chemicals Notification and Assessment Scheme (NICNAS) NIOSH (National Institute for Occupational Safety and Health) National Library of Medicine's ChemID Plus (NLM CIP) National Library of Medicine’s PubMed database (NLM PUBMED) HRLS00987 - 2X Restriction Buffer National Toxicology Program (NTP) New Zealand's Chemical Classification and Information Database (CCID) Organization for Economic Co-operation and Development Environment, Health, and Safety Publications Organization for Economic Co-operation and Development High Production Volume Chemicals Program Organization for Economic Co-operation and Development Screening Information Data Set World Health Organization Disclaimer The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text 1,2,3-Propanetriol 56-81-5 20 - 35 Database International Uniform Chemical Information Database (IUCLID) National Institute of Technology and Evaluation (NITE) Australia National Industrial Chemicals Notification and Assessment Scheme (NICNAS) NIOSH (National Institute for Occupational Safety and Health) National Library of Medicine's ChemID Plus (NLM CIP) National Library of Medicine’s PubMed database (NLM PUBMED) National Toxicology Program (NTP) New Zealand's Chemical Classification and Information Database (CCID) Organization for Economic Co-operation and Development Environment, Health, and Safety Publications Organization for Economic Co-operation and Development High Production Volume Chemicals Program Organization for Economic Co-operation and Development Screening Information Data Set World Health Organization Disclaimer The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text