Amplification Reagent 4X

2.1 Classification of the substance or mixture

Reproductive toxicity Category 1B

Signal word

Danger Warning

Hazard statements

May damage fertility or the unborn child Not classified Not a hazardous substance or mixture according to the Globally Harmonized System (GHS) Not classified Not a hazardous substance or mixture according to the Globally Harmonized System (GHS) May cause an allergic skin reaction Suspected of damaging fertility or the unborn child

Prevention

Do not handle until all safety precautions have been read and understood Wear protective gloves/clothing and eye/face protection Do not handle until all safety precautions have been read and understood Wear protective gloves/clothing and eye/face protection Avoid breathing dust/fume/gas/mist/vapors/spray _____________________________________________________________________________________________ Page 53 / 61 HRLS01007 - Streptavidin-HRP-FP106 Contaminated work clothing must not be allowed out of the workplace

Response

IF exposed or concerned: Get medical advice/attention HRLS00428 - 2X Amplification Diluent _____________________________________________________________________________________________ IF exposed or concerned: Get medical advice/attention Skin IF ON SKIN: Wash with plenty of water and soap If skin irritation or rash occurs: Get medical advice/attention Take off contaminated clothing and wash it before reuse

Precautionary statements

Disposal Dispose of contents/container in accordance with local, regional, national, and international regulations as applicable Disposal Dispose of contents/container in accordance with local, regional, national, and international regulations as applicable

Other hazards which do not result in classification

Section 3: Composition/information on ingredients Chemical name CAS No Weight-% Boric acid (H3BO3) 10043-35-3 0.3 - 0.999 Disodium stannate, trihydrate 12209-98-2 0.01 - 0.099 May be harmful if swallowed. Section 3: Composition/information on ingredients The product contains no substances which at their given concentration, are considered to be hazardous to health Chemical name CAS No Weight-% No information available. Section 3: Composition/information on ingredients Chemical name CAS No Weight-% Casein 9000-71-9 50 - 100 HRLS00536 - Blocking Reagent Section 4: First-aid measures Description of first aid measures Inhalation Remove to fresh air. Eye contact Rinse thoroughly with plenty of water for at least 15 minutes, lifting lower and upper eyelids. Consult a physician. Skin contact Wash skin with soap and water. Ingestion Rinse mouth. Most important symptoms and effects, both acute and delayed Symptoms Indication of any immediate medical attention and special treatment needed Note to physicians Treat symptomatically. Section 5: Fire-fighting measures Suitable Extinguishing Media Use extinguishing measures that are appropriate to local circumstances and the surrounding environment. Large Fire CAUTION: Use of water spray when fighting fire may be inefficient. Unsuitable extinguishing media Do not scatter spilled material with high pressure water streams. Specific hazards arising from the chemical Specific hazards arising from the chemical Special protective actions for fire-fighters Special protective equipment and Firefighters should wear self-contained breathing apparatus and full firefighting turnout precautions for fire-fighters gear. Section 6: Accidental release measures Personal precautions, protective equipment and emergency procedures Personal precautions Ensure adequate ventilation. For emergency responders Use personal protection recommended in Section 8. Environmental precautions See Section 12 for additional Ecological Information. Methods and material for containment and cleaning up Methods for containment Prevent further leakage or spillage if safe to do so. Methods for cleaning up Pick up and transfer to properly labeled containers. HRLS00536 - Blocking Reagent Precautions to prevent secondary hazards Prevention of secondary hazards Clean contaminated objects and areas thoroughly observing environmental regulations. Section 7: Handling and storage Precautions for safe handling Advice on safe handling Handle in accordance with good industrial hygiene and safety practice. Conditions for safe storage, including any incompatibilities Contains animal source material. (Cattle). Section 3: Composition/information on ingredients Chemical name CAS No Weight-% 2-Chloroacetamide 79-07-2 0.1 - 0.299 Hydrochloric acid 7647-01-0 0.01 - 0.099

Non Hazardous Components

Proprietary Balance Section 4: First-aid measures Description of first aid measures General advice Show this safety data sheet to the doctor in attendance. Inhalation Remove to fresh air. Eye contact Rinse thoroughly with plenty of water for at least 15 minutes, lifting lower and upper eyelids. Consult a physician. Skin contact Wash skin with soap and water. Ingestion Rinse mouth. Most important symptoms and effects, both acute and delayed Symptoms Indication of any immediate medical attention and special treatment needed Note to physicians Treat symptomatically. Section 5: Fire-fighting measures Suitable Extinguishing Media Use extinguishing measures that are appropriate to local circumstances and the surrounding environment. Large Fire CAUTION: Use of water spray when fighting fire may be inefficient. Unsuitable extinguishing media Do not scatter spilled material with high pressure water streams. Specific hazards arising from the chemical Specific hazards arising from the No information available. chemical Special protective actions for fire-fighters Special protective equipment and Firefighters should wear self-contained breathing apparatus and full firefighting turnout precautions for fire-fighters gear. HRLS00428 - 2X Amplification Diluent Section 6: Accidental release measures Personal precautions, protective equipment and emergency procedures Personal precautions Ensure adequate ventilation. For emergency responders Use personal protection recommended in Section 8. Environmental precautions See Section 12 for additional Ecological Information. Methods and material for containment and cleaning up Methods for containment Prevent further leakage or spillage if safe to do so. Methods for cleaning up Pick up and transfer to properly labeled containers. Precautions to prevent secondary hazards Prevention of secondary hazards Clean contaminated objects and areas thoroughly observing environmental regulations. Section 7: Handling and storage Precautions for safe handling Advice on safe handling Handle in accordance with good industrial hygiene and safety practice. Avoid contact with skin, eyes or clothing. Do not eat, drink or smoke when using this product. Remove contaminated clothing and shoes. General hygiene considerations Do not eat, drink or smoke when using this product. Wash hands before breaks and immediately after handling the product. Conditions for safe storage, including any incompatibilities Proprietary Balance Section 4: First-aid measures HRLS00502 - Phosphate Buffered Saline Description of first aid measures Inhalation Remove to fresh air. Eye contact Rinse thoroughly with plenty of water for at least 15 minutes, lifting lower and upper eyelids. Consult a physician. Skin contact Wash skin with soap and water. Ingestion Rinse mouth. Most important symptoms and effects, both acute and delayed Symptoms Indication of any immediate medical attention and special treatment needed Note to physicians Treat symptomatically. Section 5: Fire-fighting measures Suitable Extinguishing Media Use extinguishing measures that are appropriate to local circumstances and the surrounding environment. Large Fire CAUTION: Use of water spray when fighting fire may be inefficient. Unsuitable extinguishing media Do not scatter spilled material with high pressure water streams. Specific hazards arising from the chemical Specific hazards arising from the chemical Special protective actions for fire-fighters Special protective equipment and Firefighters should wear self-contained breathing apparatus and full firefighting turnout precautions for fire-fighters gear. Section 6: Accidental release measures Personal precautions, protective equipment and emergency procedures Personal precautions Ensure adequate ventilation. For emergency responders Use personal protection recommended in Section 8. Environmental precautions See Section 12 for additional Ecological Information. Methods and material for containment and cleaning up Methods for containment Prevent further leakage or spillage if safe to do so. Methods for cleaning up Pick up and transfer to properly labeled containers. Precautions to prevent secondary hazards HRLS00502 - Phosphate Buffered Saline Prevention of secondary hazards Clean contaminated objects and areas thoroughly observing environmental regulations. Section 7: Handling and storage Precautions for safe handling Advice on safe handling Handle in accordance with good industrial hygiene and safety practice. Conditions for safe storage, including any incompatibilities Proprietary Balance Section 4: First-aid measures Description of first aid measures General advice Show this safety data sheet to the doctor in attendance. Inhalation Remove to fresh air. Eye contact Rinse thoroughly with plenty of water for at least 15 minutes, lifting lower and upper eyelids. Consult a physician. Skin contact Wash with soap and water. May cause an allergic skin reaction. In the case of skin irritation or allergic reactions see a physician. Ingestion Rinse mouth. Most important symptoms and effects, both acute and delayed Symptoms Itching. Rashes. Hives. Indication of any immediate medical attention and special treatment needed Note to physicians May cause sensitization in susceptible persons. Treat symptomatically. Section 5: Fire-fighting measures Suitable Extinguishing Media Use extinguishing measures that are appropriate to local circumstances and the surrounding environment. Large Fire CAUTION: Use of water spray when fighting fire may be inefficient. Unsuitable extinguishing media Do not scatter spilled material with high pressure water streams. Specific hazards arising from the chemical HRLS01007 - Streptavidin-HRP-FP106 Specific hazards arising from the Product is or contains a sensitizer. May cause sensitization by skin contact. chemical Special protective actions for fire-fighters Special protective equipment and Firefighters should wear self-contained breathing apparatus and full firefighting turnout precautions for fire-fighters gear. Section 6: Accidental release measures Personal precautions, protective equipment and emergency procedures Personal precautions Avoid contact with skin, eyes or clothing. Ensure adequate ventilation. Use personal protective equipment as required. Evacuate personnel to safe areas. Keep people away from and upwind of spill/leak. For emergency responders Use personal protection recommended in Section 8. Environmental precautions See Section 12 for additional Ecological Information. Methods and material for containment and cleaning up Methods for containment Prevent further leakage or spillage if safe to do so. Methods for cleaning up Pick up and transfer to properly labeled containers. Precautions to prevent secondary hazards Prevention of secondary hazards Clean contaminated objects and areas thoroughly observing environmental regulations. Section 7: Handling and storage Precautions for safe handling Advice on safe handling Handle in accordance with good industrial hygiene and safety practice. Avoid contact with skin, eyes or clothing. Ensure adequate ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Do not eat, drink or smoke when using this product. Take off contaminated clothing and wash before reuse. Remove contaminated clothing and shoes. General hygiene considerations Do not eat, drink or smoke when using this product. Wash hands before breaks and immediately after handling the product. Conditions for safe storage, including any incompatibilities

Storage

Conditions Store locked up. Store according to product and label instructions. Incompatible materials None known based on information supplied. Section 8: Exposure controls/personal protection Control parameters Exposure Limits Chemical name New Zealand Australia ACGIH TLV United Kingdom Boric acid (H3BO3) - STEL: 6 mg/m3 - 10043-35-3 inhalable particulate matter TWA: 2 mg/m3 inhalable particulate matter Disodium stannate, TWA: 2 mg/m3 2 mg/m3 TWA: 2 mg/m3 Sn TWA: 2 mg/m3 trihydrate inhalable particulate STEL: 4 mg/m3 12209-98-2 matter excluding tin hydride and indium tin oxide Biological occupational exposure This product, as supplied, does not contain any hazardous materials with biological limits limits established by the region specific regulatory bodies. HRLS00428 - 2X Amplification Diluent Appropriate engineering controls Engineering controls Showers Eyewash stations Ventilation systems. Individual protection measures, such as personal protective equipment Eye/face protection No special protective equipment required. Hand protection Wear suitable gloves. Skin and body protection Wear suitable protective clothing. Respiratory protection No protective equipment is needed under normal use conditions. If exposure limits are exceeded or irritation is experienced, ventilation and evacuation may be required. Environmental exposure controls Section 9: Physical and chemical properties Information on basic physical and chemical properties Physical state Liquid Appearance aqueous solution Colour colourless Odour Odourless. Odour threshold Property Values Conditions Store according to product and label instructions. Incompatible materials None known based on information supplied. Section 8: Exposure controls/personal protection Control parameters Exposure Limits This product, as supplied, does not contain any hazardous materials with occupational exposure limits established by the region specific regulatory bodies. Biological occupational exposure This product, as supplied, does not contain any hazardous materials with biological limits limits established by the region specific regulatory bodies. Appropriate engineering controls Engineering controls Showers Eyewash stations Ventilation systems. Individual protection measures, such as personal protective equipment Eye/face protection No special protective equipment required. Hand protection No special protective equipment required. Skin and body protection No special protective equipment required. Respiratory protection No protective equipment is needed under normal use conditions. If exposure limits are exceeded or irritation is experienced, ventilation and evacuation may be required. Environmental exposure controls No information available. Section 9: Physical and chemical properties Information on basic physical and chemical properties Physical state Solid Appearance solid Colour white Odour Odourless. Odour threshold No information available Property Values Conditions Store according to product and label instructions. Incompatible materials None known based on information supplied. Section 8: Exposure controls/personal protection Control parameters Exposure Limits This product, as supplied, does not contain any hazardous materials with occupational exposure limits established by the region specific regulatory bodies. Biological occupational exposure This product, as supplied, does not contain any hazardous materials with biological limits limits established by the region specific regulatory bodies. Appropriate engineering controls Engineering controls Showers Eyewash stations Ventilation systems. Individual protection measures, such as personal protective equipment Eye/face protection No special protective equipment required. Hand protection No special protective equipment required. Skin and body protection No special protective equipment required. Respiratory protection No protective equipment is needed under normal use conditions. If exposure limits are exceeded or irritation is experienced, ventilation and evacuation may be required. Environmental exposure controls No information available. Section 9: Physical and chemical properties Information on basic physical and chemical properties Physical state Solid Appearance Powder Colour white Odour Sulphurous. Odour threshold No information available HRLS00536 - Blocking Reagent Property Values Conditions Keep containers tightly closed in a dry, cool and well-ventilated place. Store locked up. Store according to product and label instructions. Incompatible materials None known based on information supplied. Section 8: Exposure controls/personal protection Control parameters Exposure Limits HRLS01007 - Streptavidin-HRP-FP106 Australia ACGIH TLV United Kingdom Hydrochloric acid Ceiling: 5 ppm 5 ppm Peak Ceiling: 2 ppm TWA: 1 ppm 7647-01-0 Ceiling: 7.5 mg/m3 7.5 mg/m3 Peak TWA: 2 mg/m3 STEL: 5 ppm STEL: 8 mg/m3 Biological occupational exposure This product, as supplied, does not contain any hazardous materials with biological limits limits established by the region specific regulatory bodies. Appropriate engineering controls Engineering controls Showers Eyewash stations Ventilation systems. Individual protection measures, such as personal protective equipment Eye/face protection Wear safety glasses with side shields (or goggles). Hand protection Wear suitable gloves. Skin and body protection Wear suitable protective clothing. Respiratory protection No protective equipment is needed under normal use conditions. If exposure limits are exceeded or irritation is experienced, ventilation and evacuation may be required. Environmental exposure controls Section 9: Physical and chemical properties Information on basic physical and chemical properties Physical state Liquid Appearance aqueous solution Colour colourless Odour Odourless. Odour threshold Property Values

Remarks

Method pH None known Melting point / freezing point 0 °C Boiling point / boiling range >= 100 °C Flash point No data available None known Evaporation rate No data available None known Flammability (solid, gas) No data available None known Flammability Limit in Air None known Upper flammability or explosive No data available limits Lower flammability or explosive No data available limits Vapour pressure No data available None known Vapour density No data available None known Relative density No data available None known Water solubility No data available Miscible in water Solubility(ies) No data available None known Partition coefficient No data available None known Autoignition temperature No data available None known Decomposition temperature None known Kinematic viscosity No data available None known Dynamic viscosity No data available None known Explosive properties No information available. Oxidizing properties No information available. Method pH None known Melting point / freezing point No data available None known HRLS00502 - Phosphate Buffered Saline Boiling point / boiling range 1461 °C Flash point No data available None known Evaporation rate No data available None known Flammability (solid, gas) No data available None known Flammability Limit in Air None known Upper flammability or explosive No data available limits Lower flammability or explosive No data available limits Vapour pressure No data available None known Vapour density No data available None known Relative density No data available None known Water solubility No data available Soluble in water Solubility(ies) No data available None known Partition coefficient No data available None known Autoignition temperature No data available None known Decomposition temperature None known Kinematic viscosity No data available None known Dynamic viscosity No data available None known Explosive properties Chemical stability Stability Stable under normal conditions. Explosion data Sensitivity to mechanical impact None. Sensitivity to static discharge None. Possibility of hazardous reactions None under normal processing. Conditions to avoid None known based on information supplied. Incompatible materials None known based on information supplied. Hazardous decomposition products Hazardous decomposition products None known based on information supplied. Method pH None known Melting point / freezing point No data available None known Boiling point / boiling range No data available None known Flash point No data available None known Evaporation rate No data available None known Flammability (solid, gas) No data available None known Flammability Limit in Air None known Upper flammability or explosive No data available limits Lower flammability or explosive No data available limits Vapour pressure No data available None known Vapour density No data available None known Relative density No data available None known Water solubility No data available Soluble in water Solubility(ies) No data available None known Partition coefficient No data available None known Autoignition temperature No data available None known Decomposition temperature None known Kinematic viscosity No data available None known Dynamic viscosity No data available None known Explosive properties Chemical stability Stability Stable under normal conditions. Explosion data Sensitivity to mechanical impact None. Sensitivity to static discharge None. Possibility of hazardous reactions None under normal processing. Conditions to avoid None known based on information supplied. Incompatible materials None known based on information supplied. Hazardous decomposition products Hazardous decomposition products None known based on information supplied. HRLS00536 - Blocking Reagent Method pH None known Melting point / freezing point No data available None known Boiling point / boiling range No data available None known Flash point No data available None known Evaporation rate No data available None known Flammability (solid, gas) No data available None known Flammability Limit in Air None known Upper flammability or explosive No data available limits Lower flammability or explosive No data available limits Vapour pressure No data available None known Vapour density No data available None known Relative density No data available None known Water solubility No data available Miscible in water Solubility(ies) No data available None known Partition coefficient No data available None known Autoignition temperature No data available None known Decomposition temperature None known Kinematic viscosity No data available None known Dynamic viscosity No data available None known Explosive properties No information available. Oxidizing properties No information available. HRLS01007 - Streptavidin-HRP-FP106 Chemical stability Stability Stable under normal conditions. Explosion data Sensitivity to mechanical impact None. Sensitivity to static discharge None. Possibility of hazardous reactions None under normal processing. Conditions to avoid None known based on information supplied. Incompatible materials None known based on information supplied. Hazardous decomposition products Hazardous decomposition products None known based on information supplied.

Further information

Softening point No information available Molecular weight No information available VOC content No information available Liquid Density No information available Bulk density No information available Particle characteristics No information available HRLS00428 - 2X Amplification Diluent Chemical stability Stability Stable under normal conditions. Explosion data Sensitivity to mechanical impact None. Sensitivity to static discharge None. Possibility of hazardous reactions None under normal processing. Conditions to avoid None known based on information supplied. Incompatible materials None known based on information supplied. Hazardous decomposition products Hazardous decomposition products None known based on information supplied. Revision 16-Aug-2022 Revision Note Reformatted and updated existing information. Key or legend to abbreviations and acronyms used in the safety data sheet Legend Section 8: EXPOSURE CONTROLS/PERSONAL PROTECTION TWA TWA (time-weighted average) STEL STEL (Short Term Exposure Limit) Ceiling Maximum limit value * Skin designation C Carcinogen Key literature references and sources for data used to compile the SDS HRLS00428 - 2X Amplification Diluent Agency for Toxic Substances and Disease Registry (ATSDR) U.S. Environmental Protection Agency ChemView Database European Food Safety Authority (EFSA) EPA (Environmental Protection Agency) Acute Exposure Guideline Level(s) (AEGL(s)) U.S. Environmental Protection Agency Federal Insecticide, Fungicide, and Rodenticide Act U.S. Environmental Protection Agency High Production Volume Chemicals Food Research Journal Revision 16-Aug-2022 Revision Note Reformatted and updated existing information. Key or legend to abbreviations and acronyms used in the safety data sheet Legend Section 8: EXPOSURE CONTROLS/PERSONAL PROTECTION TWA TWA (time-weighted average) STEL STEL (Short Term Exposure Limit) Ceiling Maximum limit value * Skin designation C Carcinogen Key literature references and sources for data used to compile the SDS Agency for Toxic Substances and Disease Registry (ATSDR) U.S. Environmental Protection Agency ChemView Database European Food Safety Authority (EFSA) EPA (Environmental Protection Agency) Acute Exposure Guideline Level(s) (AEGL(s)) U.S. Environmental Protection Agency Federal Insecticide, Fungicide, and Rodenticide Act U.S. Environmental Protection Agency High Production Volume Chemicals Food Research Journal Revision 16-Aug-2022 Revision Note Reformatted and updated existing information. Key or legend to abbreviations and acronyms used in the safety data sheet Legend Section 8: EXPOSURE CONTROLS/PERSONAL PROTECTION TWA TWA (time-weighted average) STEL STEL (Short Term Exposure Limit) Ceiling Maximum limit value * Skin designation C Carcinogen Key literature references and sources for data used to compile the SDS Agency for Toxic Substances and Disease Registry (ATSDR) U.S. Environmental Protection Agency ChemView Database European Food Safety Authority (EFSA) EPA (Environmental Protection Agency) Acute Exposure Guideline Level(s) (AEGL(s)) U.S. Environmental Protection Agency Federal Insecticide, Fungicide, and Rodenticide Act U.S. Environmental Protection Agency High Production Volume Chemicals Food Research Journal Revision 16-Aug-2022 Revision Note Reformatted and updated existing information. Key or legend to abbreviations and acronyms used in the safety data sheet Legend Section 8: EXPOSURE CONTROLS/PERSONAL PROTECTION HRLS01007 - Streptavidin-HRP-FP106 TWA TWA (time-weighted average) STEL STEL (Short Term Exposure Limit) Ceiling Maximum limit value * Skin designation C Carcinogen Key literature references and sources for data used to compile the SDS Agency for Toxic Substances and Disease Registry (ATSDR) U.S. Environmental Protection Agency ChemView Database European Food Safety Authority (EFSA) EPA (Environmental Protection Agency) Acute Exposure Guideline Level(s) (AEGL(s)) U.S. Environmental Protection Agency Federal Insecticide, Fungicide, and Rodenticide Act U.S. Environmental Protection Agency High Production Volume Chemicals Food Research Journal

TOXICOLOGICAL INFORMATION

Acute toxicity Information on likely routes of exposure Product Information Inhalation Specific test data for the substance or mixture is not available. Eye contact Specific test data for the substance or mixture is not available. Skin contact Specific test data for the substance or mixture is not available. Ingestion Specific test data for the substance or mixture is not available. Symptoms No information available. Acute toxicity Numerical measures of toxicity Component Information Chemical name Oral LD50 Dermal LD50 Inhalation LC50 Boric acid (H3BO3) = 2660 mg/kg ( Rat ) > 2000 mg/kg ( Rabbit ) > 2.12 mg/L ( Rat ) 4 h Delayed and immediate effects as well as chronic effects from short and long-term exposure HRLS00428 - 2X Amplification Diluent IARC Boric acid (H3BO3) - 10043-35-3 - Group 2A Legend IARC (International Agency for Research on Cancer) Group 2A - Probably Carcinogenic to Humans Reproductive toxicity Contains a known or suspected reproductive toxin. Classification based on data available for ingredients. May damage fertility or the unborn child. STOT - single exposure Data used to identify the health Refer to Section 16 for Key literature references and sources for data used to compile the effects SDS. HRLS00502 - Phosphate Buffered Saline Acute toxicity Information on likely routes of exposure Product Information Inhalation Specific test data for the substance or mixture is not available. Eye contact Specific test data for the substance or mixture is not available. Skin contact Specific test data for the substance or mixture is not available. Ingestion May be harmful if swallowed. Symptoms Acute toxicity Numerical measures of toxicity The following values are calculated based on chapter 3.1 of the GHS document ATEmix (oral) 4,792.30 mg/kg Delayed and immediate effects as well as chronic effects from short and long-term exposure Skin corrosion/irritation STOT - single exposure No information available. STOT - repeated exposure No information available. Acute toxicity Information on likely routes of exposure Product Information Inhalation Specific test data for the substance or mixture is not available. Eye contact Specific test data for the substance or mixture is not available. Skin contact Specific test data for the substance or mixture is not available. Ingestion Specific test data for the substance or mixture is not available. Symptoms Reproductive toxicity No information available. STOT - single exposure No information available. STOT - repeated exposure No information available. Acute toxicity Information on likely routes of exposure Product Information Inhalation Specific test data for the substance or mixture is not available. Eye contact Specific test data for the substance or mixture is not available. Skin contact May cause sensitization by skin contact. Specific test data for the substance or mixture is not available. Repeated or prolonged skin contact may cause allergic reactions with susceptible persons. (based on components). Ingestion Specific test data for the substance or mixture is not available. Symptoms Itching. Rashes. Hives. Acute toxicity Numerical measures of toxicity HRLS01007 - Streptavidin-HRP-FP106 The following values are calculated based on chapter 3.1 of the GHS document ATEmix (oral) 33,603.00 mg/kg Component Information Chemical name Oral LD50 Dermal LD50 Inhalation LC50 2-Chloroacetamide = 138 mg/kg ( Rat ) > 2000 mg/kg ( Rat ) - Hydrochloric acid 238 - 277 mg/kg ( Rat ) > 5010 mg/kg ( Rabbit ) = 1.68 mg/L ( Rat ) 1 h Delayed and immediate effects as well as chronic effects from short and long-term exposure Skin corrosion/irritation IARC Hydrochloric acid - 7647-01-0 - Group 3 Legend IARC (International Agency for Research on Cancer) Group 3 - Not Classifiable as to Carcinogenicity in Humans Reproductive toxicity Contains a known or suspected reproductive toxin. Classification based on data available for ingredients. Suspected of damaging fertility or the unborn child. STOT - single exposure

ECOLOGICAL INFORMATION

Ecotoxicity Aquatic ecotoxicity Unknown aquatic toxicity 0 % of the mixture consists of component(s) of unknown hazards to the aquatic environment. Chemical name Algae/aquatic plants Fish Crustacea Boric acid (H3BO3) - EC50: 115 - 153mg/L (48h, Daphnia magna) Terrestrial ecotoxicty Chemical name Earthworm Avian Honeybees Boric acid (H3BO3) - Dietary Toxicity: LC50 > 5620 - ppm (Anas platyrhynchos, 5 Days) Dietary Toxicity: LC50 > 5620 ppm (Colinus virginianus, 5 Days) Persistence and degradability No information available. HRLS00428 - 2X Amplification Diluent Bioaccumulative potential Bioaccumulation Component Information Chemical name Partition coefficient Boric acid (H3BO3) -1.09 Mobility in soil Mobility Section 13: Disposal considerations Waste treatment methods Waste from residues/unused Dispose of product in packaging in a way that is consistent with the EPA Consolidation 30 products April 2021 of the Hazardous Substances (Disposal) Notice 2017 and the Act. Treat the substance using a method that changes the characteristics or composition of the substance so that the substance is no longer a hazardous substance; or export the substance from New Zealand as waste. Substances which are hazardous to human health or corrosive to metals – may be discharged into the environment if a tolerable exposure limit has been set for the substance (or a component of that substance); and the discharge does not, after reasonable mixing, result in the concentration of the substance in an environmental medium exceeding the tolerable exposure limit. If there is no tolerable exposure limit for the substance, then it may only be discharged into the environment if the substance is very rapidly converted to substances that are not hazardous substances. Dispose of in accordance with local regulations. Dispose of waste in accordance with environmental legislation. Contaminated packaging For packages that have been in direct contact with hazardous substances, the person must ensure that the package is rendered incapable of containing any substance. It must be disposed of in a manner that is consistent with the requirements for disposal of the substance that it contained, taking into account the material the package is manufactured from. Packages may only be reused or recycled if: - the substance has a physical hazard other than corrosive to metal, and has been treated to remove any residual contents of the hazardous substance; - or for substances that have a health or environmental hazard, or corrosive to metal, the contents of the residue in the package are below the threshold for the substance to be classified as hazardous in the Hazardous Substances (Hazard Classification) Notice 2020. Section 14: Transport information IATA Not regulated IMDG Not regulated Transport in bulk according to Annex II of MARPOL and the IBC Code No information available Special precautions for user Please refer to the applicable dangerous goods regulations for additional information HRLS00428 - 2X Amplification Diluent Section 15: Regulatory information Safety, health and environmental regulations/legislation specific for the substance or mixture National regulations EPA New Zealand HSNO approval To be determined code or group standard National regulations There are no applicable tolerable exposure limits or environmental exposure limits according to the EPA Controls for Hazardous Substances Certified handlers, tracking and Certified handlers are required for some substances. This includes substances requiring a controlled substance license controlled substance license, and most explosives, vertebrates toxic agents, and certain requirements fumigants. Acutely toxic substances which are a Category 1 or 2, such as pesticides also require Certified handlers. Please check the Health and Safety at Work Act 2015 for further information Tracking is required for some highly hazardous substances. These substances need to be under the control of an appropriately trained person or appropriately secured. Please check the Health and Safety at Work Act 2015 for further information Controlled substance licenses are required to possess certain explosives, vertebrate toxic agents and fumigants. See Part 7 of the Health and Safety at Work Regulation 2017 for more information International Regulations The Montreal Protocol on Substances that Deplete the Ozone Layer Not applicable The Stockholm Convention on Persistent Organic Pollutants Not applicable The Rotterdam Convention Not applicable International Inventories NZIoC Contact supplier for inventory compliance status. TSCA Contact supplier for inventory compliance status. DSL/NDSL Contact supplier for inventory compliance status. EINECS/ELINCS Contact supplier for inventory compliance status. ENCS Contact supplier for inventory compliance status. IECSC Contact supplier for inventory compliance status. KECL Contact supplier for inventory compliance status. PICCS Contact supplier for inventory compliance status. AICS Contact supplier for inventory compliance status. Legend: NZIoC - New Zealand Inventory of Chemicals TSCA - United States Toxic Substances Control Act Section 8(b) Inventory DSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances List EINECS/ELINCS - European Inventory of Existing Chemical Substances/European List of Notified Chemical Substances ENCS - Japan Existing and New Chemical Substances IECSC - China Inventory of Existing Chemical Substances KECL - Korean Existing and Evaluated Chemical Substances PICCS - Philippines Inventory of Chemicals and Chemical Substances AICS - Australian Inventory of Chemical Substances Ecotoxicity Aquatic ecotoxicity Unknown aquatic toxicity 0 % of the mixture consists of component(s) of unknown hazards to the aquatic HRLS00502 - Phosphate Buffered Saline environment. Terrestrial ecotoxicty There is no data for this product. Persistence and degradability Bioaccumulative potential Bioaccumulation There is no data for this product. Mobility in soil Mobility Section 13: Disposal considerations Waste treatment methods Waste from residues/unused Not applicable. products Not Hazardous. Dispose of in accordance with local regulations. Dispose of waste in accordance with environmental legislation. Contaminated packaging Not applicable. Not Hazardous. Section 14: Transport information IATA Not regulated IMDG Not regulated Transport in bulk according to Annex II of MARPOL and the IBC Code No information available Special precautions for user Please refer to the applicable dangerous goods regulations for additional information Section 15: Regulatory information Safety, health and environmental regulations/legislation specific for the substance or mixture National regulations EPA New Zealand HSNO approval To be determined code or group standard National regulations There are no applicable tolerable exposure limits or environmental exposure limits according to the EPA Controls for Hazardous Substances Certified handlers, tracking and Certified handlers are required for some substances. This includes substances requiring a controlled substance license controlled substance license, and most explosives, vertebrates toxic agents, and certain HRLS00502 - Phosphate Buffered Saline requirements fumigants. Acutely toxic substances which are a Category 1 or 2, such as pesticides also require Certified handlers. Please check the Health and Safety at Work Act 2015 for further information Tracking is required for some highly hazardous substances. These substances need to be under the control of an appropriately trained person or appropriately secured. Please check the Health and Safety at Work Act 2015 for further information Controlled substance licenses are required to possess certain explosives, vertebrate toxic agents and fumigants. See Part 7 of the Health and Safety at Work Regulation 2017 for more information International Regulations The Montreal Protocol on Substances that Deplete the Ozone Layer Not applicable The Stockholm Convention on Persistent Organic Pollutants Not applicable The Rotterdam Convention Not applicable International Inventories NZIoC Contact supplier for inventory compliance status. TSCA Contact supplier for inventory compliance status. DSL/NDSL Contact supplier for inventory compliance status. EINECS/ELINCS Contact supplier for inventory compliance status. ENCS Contact supplier for inventory compliance status. IECSC Contact supplier for inventory compliance status. KECL Contact supplier for inventory compliance status. PICCS Contact supplier for inventory compliance status. AICS Contact supplier for inventory compliance status. Legend: NZIoC - New Zealand Inventory of Chemicals TSCA - United States Toxic Substances Control Act Section 8(b) Inventory DSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances List EINECS/ELINCS - European Inventory of Existing Chemical Substances/European List of Notified Chemical Substances ENCS - Japan Existing and New Chemical Substances IECSC - China Inventory of Existing Chemical Substances KECL - Korean Existing and Evaluated Chemical Substances PICCS - Philippines Inventory of Chemicals and Chemical Substances AICS - Australian Inventory of Chemical Substances Ecotoxicity Aquatic ecotoxicity The environmental impact of this product has not been fully investigated. HRLS00536 - Blocking Reagent Bioaccumulative potential Bioaccumulation There is no data for this product. Mobility in soil Mobility Section 13: Disposal considerations Waste treatment methods Waste from residues/unused Not applicable. products Not Hazardous. Dispose of in accordance with local regulations. Dispose of waste in accordance with environmental legislation. Contaminated packaging Not applicable. Not Hazardous. Section 14: Transport information IATA Not regulated IMDG Not regulated Transport in bulk according to Annex II of MARPOL and the IBC Code No information available Special precautions for user Please refer to the applicable dangerous goods regulations for additional information Section 15: Regulatory information Safety, health and environmental regulations/legislation specific for the substance or mixture National regulations EPA New Zealand HSNO approval To be determined code or group standard National regulations There are no applicable tolerable exposure limits or environmental exposure limits according to the EPA Controls for Hazardous Substances Certified handlers, tracking and Certified handlers are required for some substances. This includes substances requiring a controlled substance license controlled substance license, and most explosives, vertebrates toxic agents, and certain requirements fumigants. Acutely toxic substances which are a Category 1 or 2, such as pesticides also HRLS00536 - Blocking Reagent require Certified handlers. Please check the Health and Safety at Work Act 2015 for further information Tracking is required for some highly hazardous substances. These substances need to be under the control of an appropriately trained person or appropriately secured. Please check the Health and Safety at Work Act 2015 for further information Controlled substance licenses are required to possess certain explosives, vertebrate toxic agents and fumigants. See Part 7 of the Health and Safety at Work Regulation 2017 for more information International Regulations The Montreal Protocol on Substances that Deplete the Ozone Layer Not applicable The Stockholm Convention on Persistent Organic Pollutants Not applicable The Rotterdam Convention Not applicable International Inventories NZIoC Contact supplier for inventory compliance status. TSCA Contact supplier for inventory compliance status. DSL/NDSL Contact supplier for inventory compliance status. EINECS/ELINCS Contact supplier for inventory compliance status. ENCS Contact supplier for inventory compliance status. IECSC Contact supplier for inventory compliance status. KECL Contact supplier for inventory compliance status. PICCS Contact supplier for inventory compliance status. AICS Contact supplier for inventory compliance status. Legend: NZIoC - New Zealand Inventory of Chemicals TSCA - United States Toxic Substances Control Act Section 8(b) Inventory DSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances List EINECS/ELINCS - European Inventory of Existing Chemical Substances/European List of Notified Chemical Substances ENCS - Japan Existing and New Chemical Substances IECSC - China Inventory of Existing Chemical Substances KECL - Korean Existing and Evaluated Chemical Substances PICCS - Philippines Inventory of Chemicals and Chemical Substances AICS - Australian Inventory of Chemical Substances Ecotoxicity Aquatic ecotoxicity Unknown aquatic toxicity 0 % of the mixture consists of component(s) of unknown hazards to the aquatic environment. HRLS01007 - Streptavidin-HRP-FP106 Bioaccumulative potential Bioaccumulation Component Information Chemical name Partition coefficient 2-Chloroacetamide -0.63 Mobility in soil Mobility Section 13: Disposal considerations Waste treatment methods Waste from residues/unused Dispose of product in packaging in a way that is consistent with the EPA Consolidation 30 products April 2021 of the Hazardous Substances (Disposal) Notice 2017 and the Act. Treat the substance using a method that changes the characteristics or composition of the substance so that the substance is no longer a hazardous substance; or export the substance from New Zealand as waste. Substances which are hazardous to human health or corrosive to metals – may be discharged into the environment if a tolerable exposure limit has been set for the substance (or a component of that substance); and the discharge does not, after reasonable mixing, result in the concentration of the substance in an environmental medium exceeding the tolerable exposure limit. If there is no tolerable exposure limit for the substance, then it may only be discharged into the environment if the substance is very rapidly converted to substances that are not hazardous substances. Dispose of in accordance with local regulations. Dispose of waste in accordance with environmental legislation. Contaminated packaging For packages that have been in direct contact with hazardous substances, the person must ensure that the package is rendered incapable of containing any substance. It must be disposed of in a manner that is consistent with the requirements for disposal of the substance that it contained, taking into account the material the package is manufactured from. Packages may only be reused or recycled if: - the substance has a physical hazard other than corrosive to metal, and has been treated to remove any residual contents of the hazardous substance; - or for substances that have a health or environmental hazard, or corrosive to metal, the contents of the residue in the package are below the threshold for the substance to be classified as hazardous in the Hazardous Substances (Hazard Classification) Notice 2020. Section 14: Transport information IATA Not regulated IMDG Not regulated Transport in bulk according to Annex II of MARPOL and the IBC Code No information available HRLS01007 - Streptavidin-HRP-FP106 Special precautions for user Please refer to the applicable dangerous goods regulations for additional information Section 15: Regulatory information Safety, health and environmental regulations/legislation specific for the substance or mixture National regulations EPA New Zealand HSNO approval To be determined code or group standard National regulations There are no applicable tolerable exposure limits or environmental exposure limits according to the EPA Controls for Hazardous Substances Certified handlers, tracking and Certified handlers are required for some substances. This includes substances requiring a controlled substance license controlled substance license, and most explosives, vertebrates toxic agents, and certain requirements fumigants. Acutely toxic substances which are a Category 1 or 2, such as pesticides also require Certified handlers. Please check the Health and Safety at Work Act 2015 for further information Tracking is required for some highly hazardous substances. These substances need to be under the control of an appropriately trained person or appropriately secured. Please check the Health and Safety at Work Act 2015 for further information Controlled substance licenses are required to possess certain explosives, vertebrate toxic agents and fumigants. See Part 7 of the Health and Safety at Work Regulation 2017 for more information International Regulations The Montreal Protocol on Substances that Deplete the Ozone Layer Not applicable The Stockholm Convention on Persistent Organic Pollutants Not applicable The Rotterdam Convention Not applicable International Inventories NZIoC Contact supplier for inventory compliance status. TSCA Contact supplier for inventory compliance status. DSL/NDSL Contact supplier for inventory compliance status. EINECS/ELINCS Contact supplier for inventory compliance status. ENCS Contact supplier for inventory compliance status. IECSC Contact supplier for inventory compliance status. KECL Contact supplier for inventory compliance status. PICCS Contact supplier for inventory compliance status. AICS Contact supplier for inventory compliance status. Legend: NZIoC - New Zealand Inventory of Chemicals TSCA - United States Toxic Substances Control Act Section 8(b) Inventory DSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances List EINECS/ELINCS - European Inventory of Existing Chemical Substances/European List of Notified Chemical Substances ENCS - Japan Existing and New Chemical Substances IECSC - China Inventory of Existing Chemical Substances KECL - Korean Existing and Evaluated Chemical Substances PICCS - Philippines Inventory of Chemicals and Chemical Substances AICS - Australian Inventory of Chemical Substances

Hazardous Ingredients

Database International Uniform Chemical Information Database (IUCLID) National Institute of Technology and Evaluation (NITE) Australia National Industrial Chemicals Notification and Assessment Scheme (NICNAS) NIOSH (National Institute for Occupational Safety and Health) National Library of Medicine's ChemID Plus (NLM CIP) National Library of Medicine’s PubMed database (NLM PUBMED) National Toxicology Program (NTP) New Zealand's Chemical Classification and Information Database (CCID) Organization for Economic Co-operation and Development Environment, Health, and Safety Publications Organization for Economic Co-operation and Development High Production Volume Chemicals Program Organization for Economic Co-operation and Development Screening Information Data Set World Health Organization Disclaimer The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text Database International Uniform Chemical Information Database (IUCLID) National Institute of Technology and Evaluation (NITE) Australia National Industrial Chemicals Notification and Assessment Scheme (NICNAS) NIOSH (National Institute for Occupational Safety and Health) HRLS00502 - Phosphate Buffered Saline National Library of Medicine's ChemID Plus (NLM CIP) National Library of Medicine’s PubMed database (NLM PUBMED) National Toxicology Program (NTP) New Zealand's Chemical Classification and Information Database (CCID) Organization for Economic Co-operation and Development Environment, Health, and Safety Publications Organization for Economic Co-operation and Development High Production Volume Chemicals Program Organization for Economic Co-operation and Development Screening Information Data Set World Health Organization Disclaimer The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text Not classified Not a hazardous substance or mixture according to the Globally Harmonized System (GHS) Database International Uniform Chemical Information Database (IUCLID) National Institute of Technology and Evaluation (NITE) Australia National Industrial Chemicals Notification and Assessment Scheme (NICNAS) NIOSH (National Institute for Occupational Safety and Health) National Library of Medicine's ChemID Plus (NLM CIP) HRLS00536 - Blocking Reagent National Library of Medicine’s PubMed database (NLM PUBMED) National Toxicology Program (NTP) New Zealand's Chemical Classification and Information Database (CCID) Organization for Economic Co-operation and Development Environment, Health, and Safety Publications Organization for Economic Co-operation and Development High Production Volume Chemicals Program Organization for Economic Co-operation and Development Screening Information Data Set World Health Organization Disclaimer The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text Skin sensitization Category 1 Reproductive toxicity Category 2 Database International Uniform Chemical Information Database (IUCLID) National Institute of Technology and Evaluation (NITE) Australia National Industrial Chemicals Notification and Assessment Scheme (NICNAS) NIOSH (National Institute for Occupational Safety and Health) National Library of Medicine's ChemID Plus (NLM CIP) National Library of Medicine’s PubMed database (NLM PUBMED) National Toxicology Program (NTP) New Zealand's Chemical Classification and Information Database (CCID) Organization for Economic Co-operation and Development Environment, Health, and Safety Publications Organization for Economic Co-operation and Development High Production Volume Chemicals Program Organization for Economic Co-operation and Development Screening Information Data Set World Health Organization Disclaimer The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text

Aspiration hazard

No information available. Data used to identify the health Refer to Section 16 for Key literature references and sources for data used to compile the effects SDS. No information available. Data used to identify the health Refer to Section 16 for Key literature references and sources for data used to compile the effects SDS. No information available. Data used to identify the health Refer to Section 16 for Key literature references and sources for data used to compile the effects SDS.