BC 8165 A

Hazard statements (CLP)

H251, H317, H334

Code

Statements

H251

Self-heating; may catch fire

SECTION 2: Hazards identification

Health hazards

Exclamation mark

Hazard statements

H317: May cause an allergic skin reaction. 73694BOF: May cause lung injury. H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled. H251 Self-heating may catch fire EMERGENCY OVERVIEW PHYSICAL APPEARANCE: Faintly aromatic smelling, yellow liquid. IMMEDIATE CONCERNS: CONTAINS DIPHENYLMETHANE DIISOCYANATE (CAS No. 101-68-8). INHALATION OF MDI MISTS OR VAPORS MAY CAUSE RESPIRATORY IRRITATION, BREATHLESSNESS, CHEST DISCOMFORT AND REDUCED PULMONARY FUNCTION. OVEREXPOSURE WELL ABOVE THE PEL MAY RESULT IN BRONCHITIS, BRONCHIAL SPASMS AND PULMONARY EDEMA. LONG TERM EXPOEURE TO ISOCYANATES HAS BEEN REPORTED TO CAUSE LUNG DAMAGE, INCLUDING REDUCED RESPIRATORY REACTIONS INCLUDING WHEEZING, SHORTNESS OF BREATH AND DIFFICULTY BREATHING. AVOID CONTACT WITH SKIN AND EYES. SKIN OR EYE CONTACT MAY CAUSE IRRITATION. ANIMAL TESTS AND OTHER RESEARCH INDICATE THAT SKIN CONTACT MAY PLAY A ROLE IN CAUSING RESPIRATORY SENSITIZATION.

Potential health effects

EYES: Inhalation of vapours may cause irritation of the mucous membranes of the nose, throat or trachea, breathlessness, chest discomfort, difficult breathing and reduced pulmonary function. Inhalation exposure well above the PEL may result additionally in eye irritaion, headache, chemical bronchitis, asthma-like findings or pulmonary edema. Isocyanates have also been reported to cause hypersensitivity pneumonitis, which is charachterized by flu-like symptoms, the onset of which may be delayed. Gastrointestinal symptoms include nausea, vomiting and abdominal pain. SKIN ABSORPTION: Virtually nontoxic after a single skin contact. INGESTION: Virtually nontoxic after a single ingestion. INHALATION: Of moderate toxicity after short term inhalation. REPRODUCTIVE TOXICITY REPRODUCTIVE EFFECTS: Repeated inhalative uptake of the substance did not cause damage to the reproductive organs.

Teratogenic Effects

The substance (MDI) did not cause malformation in animal studies; however, toxicity to development was observed at high doses that were toxic to the parental animals. CARCINOGENICITY: A carcinogenic potential cannot be excluded after prolonged exposure to severely irritating concentrations. These effects are not relevent to humans at occupational levels of exposure.

Medical Conditions Generally Aggravated by Exposure

The isocyanate component is a respiratory sensitizer. It may cause allergic reaction leading to asthma-like spasms of the bronchial tubes and difficulty in breathing. Medical supervision of all employeesm who handle or come into contact with isocyanates is recommended. Contact may aggravate pulmonary disorders. Persons with a history of respiratory disease or hypersensitivity should not be exposed to isocyanates. Preemployment and periodic examinations with respiratory function tests (FEV, FVC as a minimum) are suggested. Persons with asthmatic conditions,chronic bronchitis, other respiratory diseases, recurrent eczema or pulmonary sensitization should be excluded from working with isocyanates. Once aa person is diagnosed as having pulmonary sensitization (alergic asthma) to isocyanates, further exposure is not recommended.

Principle Routes of Exposure

Primary routes of exposure for liquids include eye and skin contact, ingestion and inhalation. Routes of entry for gasses include inhalation and eye contact. skin contact may be a route of entry for liquified gasses.