Desmopan KU2-88943 (NTA)

SECTION 2: Hazards identification

(Continued)

Potential health effects

ROUTE(S) OF ENTRY.......0% eoeeeeeees Inhalation; Skin Contact; Eye Contact HUMAN EFFECTS AND SYMPTOMS OF OVEREXPOSURE: Mechanical irritation can be produced if this product is introduced into the eye. At temperatures above decomposition (482 F (250 C)), hexamethylene diisocyanate(HDI) may also be liberated. The following effects reflect the

Health hazards

associated with overexposure to isocyanates. ACUTE INHALATION..............3 Isocyanate vapors at concentrations above the suggested exposure limit can irritate (burning sensation) the mucous membranes in the respiratory tract (nose, throat, lungs) causing runny nose, sore throat, coughing, chest discomfort, shortness of breath and reduced lung function (breathing obstruction). Persons with a preexisting, nonspecific bronchial hyperreactivity can respond to concentrations below the TLV with similar symptoms as well as asthma attack. Exposure well above the TLV may lead to bronchitis, bronchial spasm and pulmonary edema (fluid in lungs). These effects are usually reversible. Chemical or hypersensitive pneumonitis, with flu-like symptoms (e.g., fever, chills) has also been reported. These symptoms can be delayed up to several hours after exposure. CHRONIC INHALATION............3 As a result of previous repeated overexposures or a single large dose, certain individuals develop isocyanate sensitization (chemical asthma) which will cause them to react to a later exposure to isocyanate at levels well below the TLV. These symptoms, which can include chest tightness, wheezing, cough, shortness of breath or asthma attack, could be immediate or delayed (up to several hours after exposure). Similar to many non-specific asthmatic responses, there are reports that once sensitized an individual can experience these symptoms upon exposure to dust, cold air or other irritants. This increased lung sensitivity can persist for weeks and in severe cases for several years. Overexposure to isocyanates has also been reported to cause lung damage (including decrease in lung function) which may be permanent. Sensitization can either be temporary or permanent. ACUTE SKIN CONTACT............: Isocyanates react with skin protein and moisture and can cause irritation which may include the following symptoms: reddening, swelling, rash, scaling or blistering. CHRONIC SKIN CONTACT..........: Prolonged contact can cause reddening, swelling, rash, scaling, blistering, and in some cases, skin sensitization. Individuals who have developed a skin sensitization can develop these symptoms as a result of contact with very small amounts of liquid material or as a result of exposure to vapor. ACUTE EYE CONTACT.............: Vapors of HDI are irritating and can cause tearing, reddening and swelling. If left untreated, corneal damage can occur and injury is slow to heal. However, damage is usually reversible. See Section for First Aid measures. CHRONIC EYE CONTACT...........: None known ACUTE INGESTION...............: None known CHRONIC INGESTION.............3 None known CARCINOGENICITY Product Code: XX042594 MSDS Page 2 Approval date: 04/19/2001 Continued on next page Sr, HAZARDS IDENTIFICATION (Continued) NTP ose ererenece nie 98 eseneisce wisraxe Peete Not listed as a carcinogen TARC 6 sieiee ci 6 bn aceie oun ceveeeeeet Not listed as a carcinogen OSHA... ccc ce eecececeeceveeess Not listed as a carcinogen MEDICAL CONDITIONS AGGRAVATED BY EXPOSURE......: Exposure to HDI can affect asthma,