Desmopan Developmental Prod KU2-88390 000000

SECTION 2: Hazards identification

(Continued)

Potential health effects

ROUTE(S) OF ENTRY.......-e+---+2ee-3 Inhalation; Skin Contact; Eye Contact HUMAN EFFECTS AND SYMPTOMS OF OVEREXPOSURE: Mechanical irritation can be produced if this product is introduced into the eye. At temperatures above decomposition (482 (250 C)), hexamethylene diisocyanate(HDI) may also be liberated. The following effects reflect the potential health hazards associated with overexposure to isocyanates. ACUTE INHALATION..............8 Isocyanate vapors at concentrations above the suggested exposure limit can irritate (burning sensation) the mucous membranes in the respiratory tract (nose, throat, lungs) causing runny nose, sore throat, coughing, chest discomfort, shortness of breath and reduced lung function (breathing obstruction). Persons with a preexisting, nonspecific bronchial hyperreactivity can respond to concentrations below the TLV with similar symptoms as well as asthma attack. Exposure well above the TLV may lead to bronchitis, bronchial spasm and pulmonary edema (fluid in lungs). These effects are usually reversible. Chemical or hypersensitive pneumonitis, with flu-like symptoms (e.g., fever, chills) has also been reported. These symptoms can be delayed up to several hours after exposure. CHRONIC INHALATION............3 AS a result of previous repeated overexposures or a single large dose, certain individuals develop isocyanate sensitization (chemical asthma) which will cause them to react to a later exposure to isocyanate at levels well below the TLV. These symptoms, which can include chest tightness, wheezing, cough, shortness of breath or asthma attack, could be immediate or delayed (up to several hours after exposure). Similar to many non-specific asthmatic responses, there are reports that once sensitized an individual can experience these symptoms upon exposure to dust, cold air or other irritants. This increased lung sensitivity can persist for weeks and in severe cases for several years. Overexposure to isocyanates has also been reported to cause lung damage (including decrease in lung function) which may be permanent. Sensitization can either be temporary or permanent. ACUTE SKIN CONTACT............: Isocyanates react with skin protein and moisture and can cause irritation which may include the following symptoms: reddening, swelling, rash, scaling or blistering. CHRONIC SKIN CONTACT..........: Prolonged contact can cause reddening, swelling, rash, scaling, blistering, and in some cases, skin sensitization. Individuals who have developed a skin sensitization can develop these symptoms as a result of contact with very small amounts of Liquid material or as a result of exposure to vapor. ACUTE EYE CONTACT.............3 Vapors of HDI are irritating and can cause tearing, reddening and swelling. If left untreated, corneal damage can occur and injury is slow to heal. However, damage is usually reversible. See Section for First Aid measures. CHRONIC EYE CONTACT...........: None known ACUTE INGESTION............+--3 None known CHRONIC INGESTION............+.: None known CARCINOGENICITY Product Code: H9061000 MSDS Page Shs HAZARDS IDENTIFICATION (Continued) NTP. ccc cceceeccceecceeeseees Not listed as a carcinogen TARC. cc cece eee ence ceo eeeeees Not listed as a carcinogen OSHA... cece eevee ceccececvccees Not listed as a carcinogen MEDICAL CONDITIONS AGGRAVATED BY EXPOSURE......: Exposure to HDI can affect asthma, other respiratory disorders (bronchitis, emphysema, bronchial hyperreactivity), skin allergies, and eczema. EXPOSURE LIMITS...............: Although no exposure limit has been established for this product, the OSHA-PEL for nuisance dust of 15 mg/m3-total dust, 5 mg/m3-respirable dust is recommended. In addition, the ACGIH-TLV for nuisance dust of 10 mg/m3 is recommended. FIRST AID FOR EYES......: Flush eyes with plenty of lukewarm water for at least 15 minutes, holding eyelids open all the time. See a physician or ophthalmologist for immediate follow-up if irritation is present and persists. FIRST AID FOR SKIN......: Wash affected areas with soap and water. See physician if thermal burn occurs. FIRST AID FOR INHALATION: Remove to fresh air. FIRST AID FOR INGESTION.: Contact a physician. NOTE TO PHYSICIAN.......: The following courses of action are suggested if overexposure to HDI is suspected.