LC4500 Express Clear

SECTION 2: Hazards identification

HMIS® ratings

Health: 2¤ Flammability: 3

Physical hazards

0 HMIS uses a numbering scale ranging from 0 to 4 to indicate the degree of hazard. A value of zero means that the substance possesses essentially no hazard; a rating of four indicates high hazard. EMERGENCY OVERVIEW WARNING FLAMMABLE LIQUID HARMFUL IF INHALED CAN CAUSE CENTRAL NERVOUS SYSTEM DAMAGE CAN CAUSE LIVER DAMAGE CAN CAUSE KIDNEY DAMAGE MAY CAUSE EYE, SKIN AND RESPIRATORY TRACT IRRITATION CONTAINS A MATERIAL WHICH HAS BEEN IDENTIFIED AS A SUSPECT CANCER MAY CAUSE PULMONARY EDEMA INGESTION MAY CAUSE GASTRIC DISTURBANCES

Principle Routes of Exposure

Routes of entry for solids and liquids include eye and skin contact, ingestion and inhalation. Routes of entry for gases include inhalation and eye contact. Skin contact may be a route of entry for liquefied gases. Solvents are absorbed through the skin. Acute toxicity: Inhalation may cause CNS depression, blurred vision, dizziness and drowsiness. Overexposure may cause nausea and vomiting. Inhalation causes headache and nausea. Vapors have a suffocating effect. Intentional misuse by deliberately concentrating and inhaling this product may be harmful or fatal. Information on: 2-heptanone Inhalation of 2-heptanone (methyl amyl ketone) may lead to upper respiratory tract irritation and central nervous system effects like headache, nausea and dizziness. Information on: acetone Acute exposures to relatively large amounts of acetone can result in local effects, such as irritation to eyes, nose, throat, and respiratory tract as well as systemic effects such as central nervous system (CNS) depression, which can range in severity from lightheadedness to loss of consciousness depending on the magnitude and length of the exposure. Information on: n-butyl acetate Inhalation of butyl acetate vapors may result in headache, dizziness, nausea, irritation of the respiratory tract, and CNS depression. Prolonged inhalation exposures have been known to produce upper respiratory tract irritation and acute transient signs of reduced activity at concentrations at 1500 ppm and above in rats, with no cumulative neurotoxic effects. Overexposure may cause irritation of the eyes, nose and throat. Information on: ethyl benzene Vapors are readily absorbed through the lungs. Inhalation of ethylbenzene vapors causes drowsiness, narcosis, headaches, cramps, and tightness of the chest. Severe overexposure can cause death due to respiratory center paralysis. If aspiration occurs, chemical pneumonitis or pulmonary edema may result. Ingestion may result in kidney or liver damage. Ethyl benzene is absorbed through the skin at a low rate. Information on: methyl propyl ketone Prolonged or repeated skin contact with methyl propyl ketone may result in dermatitis. Human exposure to 1500 ppm methyl propyl ketone vapors caused irritation of the eyes and nose. Inhalation overexposure may result in narcosis and weakness. Severe overexposure may result in unconsciousness. Information on: 1,2,4 trimethylbenzene Inhalation of 1,2,4-trimethylbenzene may result in CNS effects including CNS depression, nausea, anxiety and headache. Aspiration of the liquid into the lungs may result in pulmonary edema and chemical pneumonitis. Asthmatic bronchitis may be aggravated by 1,2,4-trimethylbenzene exposure. Information on: xylene Aspiration of xylene may result in chemical pneumonitis, pulmonary edema and hemorrhage. Ingestion and skin absorption may lead to CNS depression, symptoms may include nausea, dizziness and blurred vision. Irritation: Skin contact may result in irritation, defatting and dermatitis. Vapors cause irritation to the respiratory tract and the eyes. Prolonged inhalation of product vapor can result in irritation of the mucous membranes. Information on: ethyl benzene Ethylbenzene is extremely irritating to the eyes, skin and upper respiratory tract. Eye contact may result in conjunctivitis and corneal injury. Repeated dose toxicity: Information on: 2-heptanone Repeated inhalation exposures to 2-heptanone (methyl amyl ketone) have been known to produce neurological effects in experimental animals at 1000 ppm. Repeated oral exposures in rats have been known to produce liver and kidney effects at 500 mg/kg/day. Information on: acetone High doses of acetone (500 and 2500 mg/kg/day) administered by oral gavage to rats for 90 consecutive days resulted in some clinical chemistry and blood changes as well as increased absolute/relative liver and kidney weights. Histopathological examination of both organs showed acetone did not affect the liver but appeared to accentuate the kidney changes which accompany aging. No effects were observed at 100 mg/kg/day. Chronic occupational exposures to acetone at levels ranging from 300 to 100 ppm have reportedly been associated with irritation and mild CNS effects but have not affected clinical chemistry parameters or worker mortality. Information on: n-butyl acetate In a teratogenicity study, pregnant rabbits were exposed to n-butyl acetate vapors at 0 or 1500 ppm from day 1 to day 19 of gestation; pregnant rats were exposed at the same concentrations from day 1 to day 16 of gestation. Body weight changes were observed in the rats but not the rabbits. Reproductive performance was not affected. Rabbit fetus size was not affected by exposure, but fetal size in all exposed groups of rats was reduced, suggesting embryotoxicity. Information on: ethyl benzene Animal studies indicate that chronic overexposure to ethylbenzene may cause liver and kidney injury. Increased liver and kidney weight were found in rats exposed to 400 ppm for 186 days. Animal studies indicate that the vapors may be embryotoxic. Prolonged skin contact will cause edema and blistering. In NTP 2-year inhalation studies, clear evidence of carcinogenicity of ethylbenzene in male rats was noted based on increased incidences of kidney neoplasms. Incidences of testicular adenoma were also increased. In female rats, male mice and female mice there was some evidence of carcinogenicity, based on kidney adenoma, lung neoplasms and liver neoplasms, respectively. The International Agency for Research on Cancer (IARC) has classified ethylbenzene in Category 2B, sufficient evidence of carcinogenicity in animals. Information on: 1,2,4 trimethylbenzene In a subchronic toxicity study, male rats were gavaged with either 0.5 or 2.0 g/kg 1,2,4-trimethylbenzene once daily, for 5 days/week for four weeks. Mortality occured in 1 rat from the low dose group; all rats died in the high dose group during the study. Information on: xylene The chronic effects of overexposure to xylene include possible liver and kidney damage. A mixture of o, m, and p-xylenes was teratogenic and embryo toxic to mice by the oral route; however, these effects were accompanied by maternal toxicity. Rats exposed to 1000 mg/m3 by inhalation exhibited no

Teratogenic Effects

however, minor skeletal abnormalities occurred. ______________________________________________________________________