isocyanate

SECTION 2: Hazards identification

Emergency overview DANGER: POISON. HARMFUL IF INHALED. SENSITIZATION CAN OCCUR IN SOME INDIVIDUALS, LEADING TO ASTHMA-LIKE SPASMS OF THE BRONCHIAL TUBES AND DIFFICULTY BREATHING. INDIVIDUALS WITH A HISTORY OF RESPIRATORY ILLNESS, ASTHMATIC CONDITIONS, EYE DAMAGE OR TDI SENSITIZATION SHOULD NOT BE EXPOSED TO THIS PRODUCT. TDI IS INCLUDED IN THE NTP ANNUAL REPORT ON CARCINOGENS. RESULTS FROM A TDI HEALTH STUDY INDICATE THAT OVEREXPOSURE TO A RESPIRATORY IRRITANT, RESULTING IN LOWER RESPIRATORY TRACT SYMPTOMS COULD INCREASE THE RISKS OF DEVELOPING ASTHMA-LIKE REACTIONS FROM SUBSEQUENT TDI EXPOSURE. State of matter: liquid Colour: brown Odour: sweetish, pungent odour, aromatic, biting

Principle Routes of Exposure

Routes of entry for solids and liquids include eye and skin contact, ingestion and inhalation. Routes of entry for gases include inhalation and eye contact. Skin contact may be a route of entry for liquified gases. Acute toxicity: Of very high toxicity after short-term inhalation. Virtually nontoxic after a single ingestion. Virtually nontoxic after a single skin contact. Irritation / corrosion: Irritating to eyes and skin. Assessment other acute effects: Causes temporary irritation of the respiratory tract. Sensitization: The substance may cause sensitization of the respiratory tract. Sensitization after skin contact possible. Chronic toxicity: Carcinogenicity: IARC (International Agency for Research on Cancer) has classified this substance as group 2B (The agent is possibly carcinogenic to humans). NTP listed carcinogen Repeated dose toxicity: The substance may cause damage to the lung even after repeated inhalation of low doses, as shown in animal studies. The substance may cause damage to the central nervous system after repeated ingestion of high doses. The substance may cause deafness after repeated inhalation. Reproductive toxicity: The results of animal studies gave no indication of a fertility impairing effect. Literature data.

Teratogenic Effects

No indications of a developmental toxic / teratogenic effect were seen in animal studies Literature data. Genotoxicity: The substance was mutagenic in various test systems with bacterias and cell cultures; however, these results could not be confirmed in tests with mammals. Literature data.

Medical Conditions Generally Aggravated by Exposure

overexposure Medical supervision of all employees who handle or come into contact with isocyanates is recommended. The isocyanate component is a respiratory sensitizer. It may cause allergic reaction leading to asthma-like spasms of the bronchial tubes and difficulty in breathing. Preemployment and periodic medical examinations with respiratory function tests (FEV, FVC as a minimum) are suggested. Persons with history of respiratory disease or hypersensitivity should not be exposed to this product. Persons with asthmatic conditions, chronic bronchitis, other chronic respiratory diseases, recurrent eczema or pulmonary sensitization should be excluded from working with isocyanates. Once a person is diagnosed as having pulmonary sensitization (allergic asthma) to isocyanates, further exposure is not recommended. Signs and symptoms of overexposure: Information on: TDI In sensitized individuals, sensitization reactions may be elicited by structurally similar substances. Respiratory sensitization may result in allergic (asthma-like) signs in the lower respiratory tract including wheezing, shortness of breath and difficulty breathing, the onset of which may be delayed. Repeated inhalation of high concentrations may cause lung damage, including reduced lung function, which may be permanent. Substances eliciting lower respiratory tract irritation may worsen the asthma-like reactions that may be produced by product exposures. ----------------------------------

Environmental effects

Aquatic toxicity: Acutely harmful for aquatic organisms. The inhibition of the degradation activity of activated sludge is not anticipated when introduced to biological treatment plants in appropriate low concentrations. The product may hydrolyse. The test result maybe partially due to degradation products.