Note: Ingredients listed on restricted chemical lists
EC/CAS
57-57-8
Name of the chemical
Propiolactone
Concentration
<=100
General Information
Version
8
Revision date
2026-07-22
Product name
beta-Propiolactone
Product Synonyms
2-Oxetanone
CAS No.
57-57-8
supplier name
Avocado Research Chemicals Ltd
Emergency telephone
001-201-796-7100, +32 14 57 52 99, 001-800-424-9300, 001-703-527-3887
Icons in SDS
Company Information
company name
Avocado Research Chemicals Ltd
e-mail address of the competent person responsible for the Safety Data Sheet
begel.sdsdesk@thermofisher.com
GHS Information
Signal word
Danger
Hazard Codes
Hazard statements (CLP)
H227, H315, H319, H330, H350
Hazard statements
Code
Statements
H227
Combustible liquid
Section 2
SECTION 2: Hazards identification
Physical State
Appearance/Odor
Liquid Colorless pungent Emergency Overview Combustible liquid. Causes skin irritation. Causes serious eye irritation. Fatal if inhaled. May cause cancer. Moisture sensitive. Classification of the substance or mixture Flammable liquids Category 4 Acute Inhalation Toxicity - Vapors Category 2 Skin Corrosion/Irritation Category 2 Serious Eye Damage/Eye Irritation Category 2 Carcinogenicity Category 1B Label Elements
Signal word
Danger Hazard Statements H227 - Combustible liquid H315 - Causes skin irritation H319 - Causes serious eye irritation H330 - Fatal if inhaled H350 - May cause cancer
Prevention
P201 - Obtain special instructions before use P202 - Do not handle until all safety precautions have been read and understood P210 - Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking P260 - Do not breathe dust/fume/gas/mist/vapors/spray P264 - Wash face, hands and any exposed skin thoroughly after handling P271 - Use only outdoors or in a well-ventilated area P280 - Wear eye protection/ face protection P284 - Wear respiratory protection
Response
P370 + P378 - In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish P302 + P352 - IF ON SKIN: Wash with plenty of soap and water P304 + P340 - IF INHALED: Remove person to fresh air and keep comfortable for breathing P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing P310 - Immediately call a POISON CENTER or doctor P362 + P364 - Take off contaminated clothing and wash it before reuse
Storage
P403 + P233 - Store in a well-ventilated place. Keep container tightly closed P405 - Store locked up
Disposal
P501 - Dispose of contents/ container to an approved waste disposal plant
Other physicochemical hazards
Combustible material.
Health hazards
Causes skin irritation. Causes serious eye irritation. Fatal if inhaled. May cause cancer.
Environmental hazards
Contains no substances known to be hazardous to the environment or not degradable in waste water treatment plants. Will likely be mobile in the environment due to its water solubility. The product is water soluble, and may spread in water systems. Toxic to terrestrial vertebrates. This product does not contain any known or suspected endocrine disruptors.
2.1 Classification of the substance or mixture
Flammable liquids. Category 4 Acute Inhalation Toxicity - Vapors Category 2 Skin Corrosion/Irritation Category 2 Serious Eye Damage/Eye Irritation Category 2 Carcinogenicity