Nicotine

SECTION 2: Hazards identification

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Principle Routes of Exposure

The Nicotine Transdermal Systems are thin, square with round corners patch, comprised of a white release liner, which releases easily, a layer of adhesive, and a clear backing imprinted overall with Aveva in a white repeating pattern. The Nicotine is contained within the middle (adhesive) layer. Nicotine can be toic through any exposure route. Nicotine Transdermal systems are especially hazardous if ingested. Consult a physician, if accidentally exposed. Exposure to nicotine through any route can cause irritation the the immediate site. Over exposure through any route can lead to all the symtoms listed below. Target Organs: Nicotine can attack virtually all the systems of the body, and be harmful to the fetus of a pregnant woman. Repeated exposure can lead to addiction. Medical conditions that are know to be aggravated by exposure to nicotine include cardiovascular or peripheral vascular disease, renal or hepatic insufficiency, endocrine diseases, peptic ulcer, and accelerated hypertension. Inhalation: May cause irritation, nausea, vomiting, abdominal pain, diarrhea, headache, sweating, weakness, dizziness, disturbed hearing and vision, and confusion. Prostration, hypotension, and respiratory failure may ensue with severe over exposure. Lethal doses produce convulsions quickly and death follows as a result of respiratory paralysis or cardiac failure. Exposure may be harmful to the fetus of pregnant women. MSDS Number: AVEVADDS .35.US clear Revision Date: May 7, 2007 Page 2 of 5 Skin Contact: Redness and irritation may occure at site of skin contact. More severe allergic reaction may occur on subsequent exosures. Will be absorbed through intact skin. See ingestion/inhalation. Eye Contact: Irritating on contact. May cause injury to eye tissue of not promptly removed. Ingestion: ay cause irritation, nausea, vomiting, abdominal pain, diarrhea, headache, sweating, weakness, disturbed hearing and vision, and confusion. Prostation, hopotension, and respiratory failure may ensue with severe over exposure. Lethal doses produce convuisions quickly and death follows as a result of respiratory paralysis or cardiac failure. Exposure may be harmful to the fetus of pregnant women. Inhalation: Remove to fresh air and allow to rest. Refer for medical attention. Skin Contact: Flush the skin surface with water and then dry. Do not use soap, as it may increase nicotine absorption. Nicotine may continue to be delivered to the bloodstream for several hours. Seek medical attention if there are symptoms of over exposure. Eye Contact: Flush with plenty of water for 15 munutes (remove contact lenses if easily possible). Seek medical attention if irritation persists. Ingestion: Refer for medical attention. Give a slurry of activated charcoal in water to drink. NOTE TO PHYSICIAN: A saline cathartic or sorbitol added to the first dose of activated charcoal may speed gastrointestinal passage of the system, for those who have ingested nicotine. In unconscious patients with a secure airway, instill activated carbon via nasogastric tube. IEBN RE FIGHTING MEASURES