Cyclophosphamide Injection

Athenex Pharmaceutical Division

Revision date : 2021-11-24

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GHS05 GHS07 GHS08
Health risk rating 5
Safety risk rating 1
Environmental risk rating 1

Note: Ingredients listed on restricted chemical lists

EC/CAS

7727-37-9

Name of the chemical

Nitrogen N2

Concentration

N/A

General Information

Revision date

2021-11-24

Product name

Cyclophosphamide Injection

Chemical name

2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2- oxazaphosphorine 2-oxide monohydrate

Emergency telephone

855-273-0154

Icons in SDS

GHS05 GHS07 GHS08

Company Information

company name

Athenex Pharmaceutical Division

GHS Information

Signal word

Danger

Hazard Codes

Hazard statements (CLP)

H302, H315, H317, H318, H340, H350, H360, H362, H372

Hazard statements

Code

Statements

H302

Harmful if swallowed

Section 2

2.1 Classification of the substance or mixture

Acute Oral Toxicity Category 4 substance or mixture: Skin Corrosion/Irritation Category 2 Serious Eye Damage/Eye Category 1 Irritation Skin Sensitization Category 1 Germ Cell Mutagenicity Category 1A Carcinogenicity Category 1A Reproductive Toxicity Category 1A Effects on or via lactation Effects on or via Lactation Specific Target Organ Category 1 Toxicity (Repeated Exposure) Ozone Not Applicable (b) Signal Word, Hazard statement(s), Symbol(s), and/or Precautionary statement(s):

Signal word

Warning

Hazard statements

H302 - Harmful if swallowed H315 - Causes skin irritation H317 - May cause an allergic skin reaction H318 - Causes serious eye damage H340 - May cause genetic defects H350 - May cause cancer H360 - May damage fertility or the unborn child H362 - May cause harm to breast-fed children H372 - Causes damage to organs through prolonged or repeated exposure CENTRE or doctor/physician P332 + P313 - If skin irritation occurs: Get medical advice/attention P362 - Take off contaminated clothing and wash before reuse P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing P310 - Immediately call a POISON CENTRE or doctor/physician P261 - Avoid breathing dust/fume/gas/mist/vapors/spray P272 - Contaminated work clothing should not be allowed out of the workplace P280 - Wear protective gloves/protective clothing/eye protection/ face protection P302+ P352 - IF ON SKIN: Wash with plenty of soap and water P333 + P313 - If skin irritation or rash occurs: Get medical advice/attention P321 - Specific treatment (see supplemental first aid instructions on this label) P363 - Wash contaminated clothing before reuse P263 - Avoid contact during pregnancy/while nursing P260 - Do not breathe dust/fume/gas/mist/vapors/spray P314 - Get medical attention/advice if you feel unwell P201 - Obtain special instructions before use P202 - Do not handle until all safety precautions have been read and understood P281 - Use personal protective equipment as required P308 + P313 - IF exposed or concerned: Get medical attention/advice P405 - Store locked up P264 - Wash face, hands and any exposed skin thoroughly after handling P270 - Do not eat, drink or smoke when using this product P301+ P312 - IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell P330 - Rinse mouth P501 - Dispose of contents/container to an approved waste disposal plant

Precautionary statements

P301+ P310 - IF SWALLOWED: Immediately call a POISON

Potential Acute Health Effects

May cause eye, skin and respiratory tract irritation. Individuals sensitive to this chemical or other materials in its chemical class may develop allergic reactions. This compound can cross the placenta in pregnant women. Secreted in human breast milk. Adverse effects: The most common adverse effects reported with clinical use were diarrhea, nausea, rash, and vomiting. Effects on blood and blood-forming organs have also occurred. (d) Unknown Acute Toxicity N/A

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