PROPYLENE GLYCOL USP/EP K

SECTION 2: Hazards identification

OSHA Emergency Overview Appearance: liquid,, Colorless CAUTION! MAY AFFECT THE CENTRAL NERVOUS SYSTEM CAUSING DIZZINESS, HEADACHE OR NAUSEA. NOTICE: WHILE THIS MATERIAL HAS A LOW LEVEL OF TOXICITY, GOOD INDUSTRIAL HYGIENE PRACTICES ARE ENCOURAGED TO MINIMIZE EXPOSURE.

Principle Routes of Exposure

Inhalation, Skin absorption, Skin contact, Eye Contact, Ingestion Eye contact May cause mild eye irritation. Symptoms include stinging, tearing, and redness. Skin contact May cause mild skin irritation. Symptoms may include redness and burning of skin. Although rare, skin contact with propylene glycol may cause allergic skin reaction (delayed skin rash which may be followed by blistering, scaling and other skin effects). Passage of this material into the body through the skin is possible, but it is unlikely that this would result in harmful effects during safe handling and use. Ingestion Swallowing this material is not likely to be harmful. Inhalation It is possible to breathe this material under certain conditions of handling and use (for example, during heating, spraying, or stirring). Breathing small amounts of this material is not likely to be harmful.

Medical Conditions Generally Aggravated by Exposure

Preexisting disorders of the following organs (or organ systems) may be aggravated by exposure to this material:, lung (for example, asthma-like conditions), kidney Symptoms Signs and symptoms of exposure to this material through breathing, swallowing, and/or passage of the material through the skin may include:, irritation (nose, throat, airways), central nervous system depression (dizziness, drowsiness, weakness, fatigue, nausea, headache, unconsciousness) Target Organs Overexposure to this material (or its components) has been suggested as a cause of the following effects in laboratory animals:, kidney damage Carcinogenicity This material is not expected to cause cancer in humans since it did not cause cancer in laboratory animals. This material is not listed as a carcinogen by the International Agency for Research on Cancer (IARC), the National Toxicology Program

Further information

Propylene glycol may be absorbed in potentially harmful amounts when applied in large quantities to severe burns (second or third degree) over large areas of the body as part of a cream or other topical application. Absorption under such circumstances can elevate serum osmolality and may result in osmotic shock.