Columbus, OH 43216

SECTION 2: Hazards identification

Emergency Overview Appearance: liquid, clear DANGER! EXTREMELY FLAMMABLE LIQUID AND VAPOR. VAPOR MAY CAUSE FLASH FIRE. MAY AFFECT THE CENTRAL NERVOUS SYSTEM CAUSING DIZZINESS, HEADACHE OR NAUSEA. MAY BE HARMFUL IF INHALED. MAY CAUSE EYE IRRITATION. MAY CAUSE SKIN AND RESPIRATORY TRACT IRRITATION.PROLONGED OR REPEATED CONTACT MAY DRY SKIN AND CAUSE DERMATITIS AND BURNS. MAY CAUSE ALLERGIC SKIN REACTION.

Principle Routes of Exposure

Inhalation, Skin absorption, Skin contact, Eye Contact, Ingestion Eye contact Can cause eye irritation. Symptoms include stinging, tearing, redness, and swelling of eyes. Skin contact Can cause skin irritation. Prolonged or repeated contact may dry the skin. Symptoms may include redness, burning, and drying and cracking of skin, burns and other skin damage. Additional symptoms of skin contact may include: Blistering allergic skin reaction (delayed skin rash which may be followed by blistering, scaling and other skin effects) Passage of this material into the body through the skin is possible, but it is unlikely that this would result in harmful effects during safe handling and use. Ingestion Swallowing small amounts of this material during normal handling is not likely to cause harmful effects. Swallowing large amounts may be harmful. This material can get into the lungs during swallowing or vomiting. This results in lung inflammation and other lung injury. Exposure causes severe irritation of the gastrointestinal tract. Inhalation Breathing of vapor or mist is possible. Breathing small amounts of this material during normal handling is not likely to cause harmful effects. Breathing large amounts may be harmful. Symptoms are not expected at air concentrations below the recommended exposure limits, if applicable (see Section 8.).

Medical Conditions Generally Aggravated by Exposure

Preexisting disorders of the following organs (or organ systems) may be aggravated by exposure to this material:, respiratory tract, skin, lung (for example, asthma-like conditions), kidney, central nervous system, blood-forming system, auditory system, Individuals with preexisting heart disorders maybe more susceptible to arrhythmias (irregular heartbeats) if exposed to high concentrations of this material. Symptoms Signs and symptoms of exposure to this material through breathing, swallowing, and/or passage of the material through the skin may include:, metallic taste, stomach or intestinal upset (nausea, vomiting, diarrhea), irritation (nose, throat, airways), lung irritation, central nervous system excitation (giddiness, liveliness, light-headed feeling) followed by central nervous system depression (dizziness, drowsiness, weakness, fatigue, nausea, headache, unconsciousness) and other central nervous system effects, temporary changes in mood and behavior, loss of appetite, weakness, low blood pressure, mild, temporary changes in the liver, effects on heart rate, respiratory depression (slowing of the breathing rate), loss of coordination, confusion, difficult breathing, irregular heartbeat, narcosis (dazed or sluggish feeling), lung edema (fluid buildup in the lung tissue), kidney damage, coma, and death Target Organs Breathing isopropanol vapors has caused damage to the lining of the middle ear in experimental animals. The relevance of this finding to humans is uncertain., Prolonged intentional toluene abuse may lead to damage to many organ systems having effects on: central and peripheral nervous systems, vision, hearing, liver, kidneys, heart and blood. Such abuse has been associated with brain damage characterized by disturbances in gait, personality changes and loss of memory. Comparable central nervous system effects have not been shown to result from occupational exposure to toluene., Prolonged intentional toluene abuse may lead to hearing loss progressing to deafness. In addition, while noise is known to cause hearing loss in humans, it has been suggested that workers exposed to organic solvents, including toluene, along with noise may suffer greater hearing loss than would be expected from exposure to noise alone., Overexposure to this material (or its components) has been suggested as a cause of the following effects in laboratory animals:, mild, reversible liver effects, mild, reversible kidney effects, blood abnormalities, cardiac sensitization, male reproductive effects, effects on hearing, effects on hearing, respiratory tract damage (nose, throat, and airways), central nervous system damage, Overexposure to this material (or its components) has been suggested as a cause of the following effects in humans:, cardiac sensitization, kidney damage Carcinogenicity Vinyl acetate caused an increase in cancer of the nasal cavity in rats. The relevance of this finding to humans is uncertain. The International Agency for Research on Cancer (IARC) reclassified this chemical from Group 3 (not able to be classified) to Group 2B (possibly carcinogenic in humans) in 1995. This classification is based on the study in rats, along with knowledge that vinyl acetate is changed to acetaldehyde, a known animal carcinogen, in the body. Reproductive hazard This material (or a component) has been shown to cause harm to the fetus in laboratory animal studies. Harm to the fetus occurs only at exposure levels that harm the pregnant animal. The relevance of these findings to humans is uncertain., Toluene may be harmful to the human fetus based on positive test results with laboratory animals. Case studies show that prolonged intentional abuse of toluene during pregnancy can cause birth defects in humans.