RNA Isolation Kit, Part Number 200345

Hazard statements (CLP)

H225, H301, H301+H311+H331, H302, H302+H332, H310, H310+H330, H311, H314, H315, H317, H318, H319, H330, H331, H332, H335, H336, H341, H351, H361d, H372, H373, H411, H412

Code

Statements

H225

Highly Flammable liquid and vapour

SECTION 2: Hazards identification

Classification according to Regulation (EC) No. 1272/2008 [CLP/GHS]]

Product definition

ß-Mercaptoethanol Mono-constituent substance Isopropanol Mono-constituent substance Denaturing solution Mixture 2M Sodium Acetate Mixture RNA Phenol pH 5.3 - 5.7 Mixture Equilibrated with Succinic Acid RNA Isolation Mixture Chloroform, Isoamyl Alcohol

CLP CLASSIFICATION

ß-Mercaptoethanol H301 ACUTE TOXICITY (oral) - Category 3 H310 ACUTE TOXICITY (dermal) - Category 2 H330 ACUTE TOXICITY (inhalation) - Category 2 H315 SKIN CORROSION/IRRITATION - Category 2 H318 SERIOUS EYE DAMAGE/EYE IRRITATION - Category 1 H317 SKIN SENSITISATION - Category 1 H335 SPECIFIC TARGET ORGAN TOXICITY - SINGLE EXPOSURE (Respiratory tract irritation) - Category 3 H411 LONG-TERM (CHRONIC) AQUATIC HAZARD - Category 2 Isopropanol H225 FLAMMABLE LIQUIDS - Category 2 H319 SERIOUS EYE DAMAGE/EYE IRRITATION - Category 2 H336 SPECIFIC TARGET ORGAN TOXICITY - SINGLE EXPOSURE (Narcotic effects) - Category 3 Denaturing solution H302 ACUTE TOXICITY (oral) - Category 4 H332 ACUTE TOXICITY (inhalation) - Category 4 H412 LONG-TERM (CHRONIC) AQUATIC HAZARD - Category 3 2M Sodium Acetate H315 SKIN CORROSION/IRRITATION - Category 2 H319 SERIOUS EYE DAMAGE/EYE IRRITATION - Category 2 RNA Phenol pH 5.3 - 5.7 Equilibrated with Succinic Acid H301 ACUTE TOXICITY (oral) - Category 3 H311 ACUTE TOXICITY (dermal) - Category 3 H331 ACUTE TOXICITY (inhalation) - Category 3 H314 SKIN CORROSION/IRRITATION - Category 1B H341 GERM CELL MUTAGENICITY - Category 2 H373 SPECIFIC TARGET ORGAN TOXICITY - REPEATED EXPOSURE - Category 2 RNA Isolation Chloroform, Isoamyl Alcohol H302 ACUTE TOXICITY (oral) - Category 4 H331 ACUTE TOXICITY (inhalation) - Category 3 H315 SKIN CORROSION/IRRITATION - Category 2 H319 SERIOUS EYE DAMAGE/EYE IRRITATION - Category 2 H351 CARCINOGENICITY - Category 2 H361d REPRODUCTIVE TOXICITY (Unborn child) - Category 2 H372 SPECIFIC TARGET ORGAN TOXICITY - REPEATED EXPOSURE - Category 1 Ingredients of unknown : 2M Sodium Acetate Percentage of the mixture consisting of ingredient(s) of toxicity unknown dermal toxicity: 10 - 30% Percentage of the mixture consisting of ingredient(s) of unknown inhalation toxicity: 10 - 30% RNA Phenol pH 5.3 - 5.7 Percentage of the mixture consisting of ingredient(s) of Equilibrated with Succinic unknown dermal toxicity: 1 - 10% Acid Percentage of the mixture consisting of ingredient(s) of unknown inhalation toxicity: 1 - 10% See Section 16 for the full text of the H statements declared above. See Section 11 for more detailed information on health effects and symptoms.

Hazard pictograms

ß-Mercaptoethanol Isopropanol Denaturing solution 2M Sodium Acetate RNA Phenol pH 5.3 - 5.7 Equilibrated with Succinic Acid RNA Isolation Chloroform, Isoamyl Alcohol

Signal word

ß-Mercaptoethanol Danger Isopropanol Danger Denaturing solution Warning 2M Sodium Acetate Warning RNA Phenol pH 5.3 - 5.7 Danger Equilibrated with Succinic Acid RNA Isolation Danger Chloroform, Isoamyl Alcohol

Hazard statements

ß-Mercaptoethanol H310 + H330 - Fatal in contact with skin or if inhaled. H301 - Toxic if swallowed. H318 - Causes serious eye damage. H315 - Causes skin irritation. H317 - May cause an allergic skin reaction. H335 - May cause respiratory irritation. H411 - Toxic to aquatic life with long lasting effects. Isopropanol H225 - Highly flammable liquid and vapour. H319 - Causes serious eye irritation. H336 - May cause drowsiness or dizziness. Denaturing solution H302 + H332 - Harmful if swallowed or if inhaled. H412 - Harmful to aquatic life with long lasting effects. 2M Sodium Acetate H319 - Causes serious eye irritation. H315 - Causes skin irritation. RNA Phenol pH 5.3 - 5.7 H301 + H311 + H331 - Toxic if swallowed, in contact with Equilibrated with skin or if inhaled. Succinic Acid H314 - Causes severe skin burns and eye damage. H341 - Suspected of causing genetic defects. H373 - May cause damage to organs through prolonged or repeated exposure. RNA Isolation H331 - Toxic if inhaled. Chloroform, Isoamyl Alcohol H302 - Harmful if swallowed. H319 - Causes serious eye irritation. H315 - Causes skin irritation. H361d - Suspected of damaging the unborn child. H351 - Suspected of causing cancer. H372 - Causes damage to organs through prolonged or repeated exposure.

Prevention

ß-Mercaptoethanol P280 - Wear protective gloves. Wear protective clothing. Wear eye or face protection. P273 - Avoid release to the environment. P262 - Do not get in eyes, on skin, or on clothing. P260 - Do not breathe vapour. Isopropanol P280 - Wear protective gloves. Wear protective clothing. Wear eye or face protection. P210 - Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. Denaturing solution P271 - Use only outdoors or in a well-ventilated area. P273 - Avoid release to the environment. P261 - Avoid breathing vapour. 2M Sodium Acetate P280 - Wear protective gloves. Wear eye or face protection. P264 - Wash hands thoroughly after handling. RNA Phenol pH 5.3 - 5.7 P201 - Obtain special instructions before use. Equilibrated with Succinic Acid P280 - Wear protective gloves. Wear protective clothing. Wear eye or face protection. P260 - Do not breathe vapour. RNA Isolation P201 - Obtain special instructions before use. Chloroform, Isoamyl Alcohol P280 - Wear protective gloves. Wear protective clothing. Wear eye or face protection. P260 - Do not breathe vapour.

Response

ß-Mercaptoethanol P304 + P340 + P310 - IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER or physician. P301 + P310 - IF SWALLOWED: Immediately call a POISON CENTER or physician. P302 + P310 - IF ON SKIN: Immediately call a POISON CENTER or physician. P305 + P310 - IF IN EYES: Immediately call a POISON CENTER or physician. Isopropanol P304 + P340 - IF INHALED: Remove person to fresh air and keep comfortable for breathing. P303 + P361 + P353 - IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water. Denaturing solution P304 + P340 + P312 - IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER or physician if you feel unwell. 2M Sodium Acetate P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. RNA Phenol pH 5.3 - 5.7 P304 + P340 + P310 - IF INHALED: Remove person to Equilibrated with fresh air and keep comfortable for breathing. Immediately Succinic Acid call a POISON CENTER or physician. P301 + P310 + P331 - IF SWALLOWED: Immediately call a POISON CENTER or physician. Do NOT induce vomiting. P303 + P361 + P353 + P310 - IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water. Immediately call a POISON CENTER or physician. P305 + P310 - IF IN EYES: Immediately call a POISON CENTER or physician. RNA Isolation P304 + P340 + P311 - IF INHALED: Remove person to Chloroform, Isoamyl fresh air and keep comfortable for breathing. Call a POISON Alcohol CENTER or physician.

Storage

ß-Mercaptoethanol P405 - Store locked up. Isopropanol P405 - Store locked up. Denaturing solution Not applicable. 2M Sodium Acetate Not applicable. RNA Phenol pH 5.3 - 5.7 P405 - Store locked up. Equilibrated with Succinic Acid RNA Isolation P405 - Store locked up. Chloroform, Isoamyl Alcohol

Disposal

ß-Mercaptoethanol P501 - Dispose of contents and container in accordance with all local, regional, national and international regulations. Isopropanol P501 - Dispose of contents and container in accordance with all local, regional, national and international regulations. Denaturing solution P501 - Dispose of contents and container in accordance with all local, regional, national and international regulations. 2M Sodium Acetate Not applicable. RNA Phenol pH 5.3 - 5.7 P501 - Dispose of contents and container in accordance Equilibrated with with all local, regional, national and international regulations. Succinic Acid RNA Isolation P501 - Dispose of contents and container in accordance Chloroform, Isoamyl with all local, regional, national and international regulations. Alcohol

Hazardous Ingredients

Denaturing solution - salts of thiocyanic acid 2M Sodium Acetate Not applicable. RNA Phenol pH 5.3 - 5.7 - phenol Equilibrated with Succinic Acid RNA Isolation - trichloromethane Chloroform, Isoamyl Alcohol

Supplemental label elements

ß-Mercaptoethanol Not applicable. elements Isopropanol Not applicable. Denaturing solution Not applicable. 2M Sodium Acetate Not applicable. RNA Phenol pH 5.3 - 5.7 Not applicable. Equilibrated with Succinic Acid RNA Isolation Not applicable. Chloroform, Isoamyl Alcohol Annex XVII - Restrictions : ß-Mercaptoethanol Not applicable. on the manufacture, Isopropanol Not applicable. placing on the market Denaturing solution Not applicable. and use of certain 2M Sodium Acetate Not applicable. dangerous substances, RNA Phenol pH 5.3 - 5.7 Not applicable. mixtures and articles Equilibrated with Succinic Acid RNA Isolation For use in industrial installations only. Chloroform, Isoamyl Alcohol

Special packaging requirements

Tactile warning of ß-Mercaptoethanol Not applicable. danger Isopropanol Not applicable. Denaturing solution Not applicable. 2M Sodium Acetate Not applicable. RNA Phenol pH 5.3 - 5.7 Not applicable. Equilibrated with Succinic Acid RNA Isolation Not applicable. Chloroform, Isoamyl Alcohol

2.3 Other hazards

Other hazards which do : ß-Mercaptoethanol None known. not result in Isopropanol None known.

Classifications

Denaturing solution None known. 2M Sodium Acetate None known. RNA Phenol pH 5.3 - 5.7 Causes digestive tract burns. Equilibrated with Succinic Acid RNA Isolation None known. Chloroform, Isoamyl Alcohol