SureSelect XT Reagent Kit - HSQ/MSQ

Hazard statements (CLP)

H314, H315, H318, H319, H402

Code

Statements

H314

Causes severe skin burns and eye damage

2.1 Classification of the substance or mixture

SureSelect Hyb 1 H319 SERIOUS EYE DAMAGE/ EYE IRRITATION - Category 2A SureSelect Hyb 4 H402 ACUTE AQUATIC HAZARD - Category 3 SureSelect Elution Buffer H314 SKIN CORROSION/IRRITATION - Category 1 H318 SERIOUS EYE DAMAGE/ EYE IRRITATION - Category 1 SureSelect Neutralization Buffer H315 SKIN CORROSION/IRRITATION - Category 2 H319 SERIOUS EYE DAMAGE/ EYE IRRITATION - Category 2A 10X End Repair Buffer Percentage of the mixture consisting of ingredient(s) of unknown toxicity: 7.9% 5X T4 DNA Ligase Buffer Percentage of the mixture consisting of ingredient(s) of unknown toxicity: 3.9% Klenow DNA Polymerase Not applicable. T4 DNA Ligase Not applicable. T4 DNA Polymerase Not applicable. T4 Polynucleotide Kinase Not applicable. dNTP Mix Percentage of the mixture consisting of ingredient(s) of unknown toxicity: 4.8% 10X Klenow Polymerase Percentage of the mixture consisting of ingredient(s) Buffer of unknown toxicity: 7.9% Exo(-) Klenow Not applicable. dATP Not applicable. SureSelect Adaptor Oligo Mix Not applicable. SureSelect Primer Not applicable. PCR Primer Index 1 Not applicable. PCR Primer Index 2 Not applicable. PCR Primer Index 3 Not applicable. PCR Primer Index 4 Not applicable. PCR Primer Index 5 Not applicable. PCR Primer Index 6 Not applicable. PCR Primer Index 7 Not applicable. PCR Primer Index 8 Not applicable. PCR Primer Index 9 Not applicable. PCR Primer Index 10 Not applicable. PCR Primer Index 11 Not applicable. PCR Primer Index 12 Not applicable. PCR Primer Index 13 Not applicable. PCR Primer Index 14 Not applicable. PCR Primer Index 15 Not applicable. PCR Primer Index 16 Not applicable. SureSelect Hyb 1 Not applicable. SureSelect Hyb 2 Not applicable. SureSelect Hyb 4 Not applicable. SureSelect Binding Buffer Not applicable. SureSelect Wash Buffer 1 Not applicable. SureSelect Wash Buffer 2 Not applicable. SureSelect Elution Buffer Not applicable. SureSelect Neutralization Percentage of the mixture consisting of ingredient(s) Buffer of unknown toxicity: 15.8% SureSelect RNase Block Not applicable. SureSelect ILM Indexing Not applicable. Post Capture Forward PCR Primer SureSelect Hyb 3 Percentage of the mixture consisting of ingredient(s) of unknown toxicity: 2% SureSelect Block 2 Not applicable. Date of issue/ Date of : 31/03/2016 Date of issue/ Date of : 27/02/2014. Version : 3 3/120 SureSelect Indexing Block 1 Not applicable. SureSelect Indexing Block 3 Not applicable. SureSelect ILM Index Pre Not applicable. Capture PCR Reverse Primer 10X End Repair Buffer Percentage of the mixture consisting of ingredient(s) of unknown hazards to the aquatic environment: 9.3% 5X T4 DNA Ligase Buffer Percentage of the mixture consisting of ingredient(s) of unknown hazards to the aquatic environment: 4.9% Klenow DNA Polymerase Not applicable. T4 DNA Ligase Not applicable. T4 DNA Polymerase Not applicable. T4 Polynucleotide Kinase Not applicable. dNTP Mix Percentage of the mixture consisting of ingredient(s) of unknown hazards to the aquatic environment: 4.8% 10X Klenow Polymerase Percentage of the mixture consisting of ingredient(s) Buffer of unknown hazards to the aquatic environment: 9.3% Exo(-) Klenow Not applicable. dATP Not applicable. SureSelect Adaptor Oligo Mix Not applicable. SureSelect Primer Not applicable. PCR Primer Index 1 Not applicable. PCR Primer Index 2 Not applicable. PCR Primer Index 3 Not applicable. PCR Primer Index 4 Not applicable. PCR Primer Index 5 Not applicable. PCR Primer Index 6 Not applicable. PCR Primer Index 7 Not applicable. PCR Primer Index 8 Not applicable. PCR Primer Index 9 Not applicable. PCR Primer Index 10 Not applicable. PCR Primer Index 11 Not applicable. PCR Primer Index 12 Not applicable. PCR Primer Index 13 Not applicable. PCR Primer Index 14 Not applicable. PCR Primer Index 15 Not applicable. PCR Primer Index 16 Not applicable. SureSelect Hyb 1 Not applicable. SureSelect Hyb 2 Not applicable. SureSelect Hyb 4 Not applicable. SureSelect Binding Buffer Not applicable. SureSelect Wash Buffer 1 Not applicable. SureSelect Wash Buffer 2 Not applicable. SureSelect Elution Buffer Not applicable. SureSelect Neutralization Percentage of the mixture consisting of ingredient(s) Buffer of unknown hazards to the aquatic environment: 15. 8% SureSelect RNase Block Not applicable. SureSelect ILM Indexing Not applicable. Post Capture Forward PCR Primer SureSelect Hyb 3 Percentage of the mixture consisting of ingredient(s) of unknown hazards to the aquatic environment: 2% SureSelect Block 2 Not applicable. SureSelect Indexing Block 1 Not applicable. SureSelect Indexing Block 3 Not applicable. SureSelect ILM Index Pre Not applicable. Capture PCR Reverse Primer

2.2 Label elements

Date of issue/ Date of : 31/03/2016 Date of issue/ Date of : 27/02/2014. Version : 3 4/120

Signal word

10X End Repair Buffer No signal word. 5X T4 DNA Ligase Buffer No signal word. Klenow DNA Polymerase No signal word. T4 DNA Ligase No signal word. T4 DNA Polymerase No signal word. T4 Polynucleotide Kinase No signal word. dNTP Mix No signal word. 10X Klenow Polymerase No signal word. Buffer Exo(-) Klenow No signal word. dATP No signal word. SureSelect Adaptor Oligo Mix No signal word. SureSelect Primer No signal word. PCR Primer Index 1 No signal word. PCR Primer Index 2 No signal word. PCR Primer Index 3 No signal word. PCR Primer Index 4 No signal word. PCR Primer Index 5 No signal word. PCR Primer Index 6 No signal word. PCR Primer Index 7 No signal word. PCR Primer Index 8 No signal word. PCR Primer Index 9 No signal word. PCR Primer Index 10 No signal word. PCR Primer Index 11 No signal word. PCR Primer Index 12 No signal word. PCR Primer Index 13 No signal word. PCR Primer Index 14 No signal word. PCR Primer Index 15 No signal word. PCR Primer Index 16 No signal word. SureSelect Hyb 1 WARNING SureSelect Hyb 2 No signal word. SureSelect Hyb 4 No signal word. SureSelect Binding Buffer No signal word. SureSelect Wash Buffer 1 No signal word. SureSelect Wash Buffer 2 No signal word. SureSelect Elution Buffer DANGER SureSelect Neutralization WARNING Buffer SureSelect RNase Block No signal word. SureSelect ILM Indexing No signal word. Post Capture Forward PCR Primer SureSelect Hyb 3 No signal word. SureSelect Block 2 No signal word. SureSelect Indexing Block 1 No signal word. SureSelect Indexing Block 3 No signal word. SureSelect ILM Index Pre No signal word. Capture PCR Reverse Primer

Hazard statements

10X End Repair Buffer No known significant effects or critical hazards. 5X T4 DNA Ligase Buffer No known significant effects or critical hazards. Klenow DNA Polymerase No known significant effects or critical hazards. T4 DNA Ligase No known significant effects or critical hazards. T4 DNA Polymerase No known significant effects or critical hazards. T4 Polynucleotide Kinase No known significant effects or critical hazards. dNTP Mix No known significant effects or critical hazards. 10X Klenow Polymerase No known significant effects or critical hazards. Buffer Date of issue/ Date of : 31/03/2016 Date of issue/ Date of : 27/02/2014. Version : 3 5/120 Exo(-) Klenow No known significant effects or critical hazards. dATP No known significant effects or critical hazards. SureSelect Adaptor Oligo Mix No known significant effects or critical hazards. SureSelect Primer No known significant effects or critical hazards. PCR Primer Index 1 No known significant effects or critical hazards. PCR Primer Index 2 No known significant effects or critical hazards. PCR Primer Index 3 No known significant effects or critical hazards. PCR Primer Index 4 No known significant effects or critical hazards. PCR Primer Index 5 No known significant effects or critical hazards. PCR Primer Index 6 No known significant effects or critical hazards. PCR Primer Index 7 No known significant effects or critical hazards. PCR Primer Index 8 No known significant effects or critical hazards. PCR Primer Index 9 No known significant effects or critical hazards. PCR Primer Index 10 No known significant effects or critical hazards. PCR Primer Index 11 No known significant effects or critical hazards. PCR Primer Index 12 No known significant effects or critical hazards. PCR Primer Index 13 No known significant effects or critical hazards. PCR Primer Index 14 No known significant effects or critical hazards. PCR Primer Index 15 No known significant effects or critical hazards. PCR Primer Index 16 No known significant effects or critical hazards. SureSelect Hyb 1 H319 - Causes serious eye irritation. SureSelect Hyb 2 No known significant effects or critical hazards. SureSelect Hyb 4 H402 - Harmful to aquatic life. SureSelect Binding Buffer No known significant effects or critical hazards. SureSelect Wash Buffer 1 No known significant effects or critical hazards. SureSelect Wash Buffer 2 No known significant effects or critical hazards. SureSelect Elution Buffer H314 - Causes severe skin burns and eye damage. SureSelect Neutralization H319 - Causes serious eye irritation. Buffer H315 - Causes skin irritation. SureSelect RNase Block No known significant effects or critical hazards. SureSelect ILM Indexing No known significant effects or critical hazards. Post Capture Forward PCR Primer SureSelect Hyb 3 No known significant effects or critical hazards. SureSelect Block 2 No known significant effects or critical hazards. SureSelect Indexing Block 1 No known significant effects or critical hazards. SureSelect Indexing Block 3 No known significant effects or critical hazards. SureSelect ILM Index Pre No known significant effects or critical hazards. Capture PCR Reverse Primer

Prevention

10X End Repair Buffer Not applicable. 5X T4 DNA Ligase Buffer Not applicable. Klenow DNA Polymerase Not applicable. T4 DNA Ligase Not applicable. T4 DNA Polymerase Not applicable. T4 Polynucleotide Kinase Not applicable. dNTP Mix Not applicable. 10X Klenow Polymerase Not applicable. Buffer Exo(-) Klenow Not applicable. dATP Not applicable. SureSelect Adaptor Oligo Mix Not applicable. SureSelect Primer Not applicable. PCR Primer Index 1 Not applicable. PCR Primer Index 2 Not applicable. PCR Primer Index 3 Not applicable. PCR Primer Index 4 Not applicable. PCR Primer Index 5 Not applicable. PCR Primer Index 6 Not applicable. PCR Primer Index 7 Not applicable. PCR Primer Index 8 Not applicable. Date of issue/ Date of : 31/03/2016 Date of issue/ Date of : 27/02/2014. Version : 3 6/120 PCR Primer Index 9 Not applicable. PCR Primer Index 10 Not applicable. PCR Primer Index 11 Not applicable. PCR Primer Index 12 Not applicable. PCR Primer Index 13 Not applicable. PCR Primer Index 14 Not applicable. PCR Primer Index 15 Not applicable. PCR Primer Index 16 Not applicable. SureSelect Hyb 1 P280 - Wear eye or face protection. P264 - Wash hands thoroughly after handling. SureSelect Hyb 2 Not applicable. SureSelect Hyb 4 P273 - Avoid release to the environment. SureSelect Binding Buffer Not applicable. SureSelect Wash Buffer 1 Not applicable. SureSelect Wash Buffer 2 Not applicable. SureSelect Elution Buffer P280 - Wear protective gloves. Wear eye or face protection. Wear protective clothing. P264 - Wash hands thoroughly after handling. SureSelect Neutralization P280 - Wear protective gloves. Wear eye or face Buffer protection. P264 - Wash hands thoroughly after handling. SureSelect RNase Block Not applicable. SureSelect ILM Indexing Not applicable. Post Capture Forward PCR Primer SureSelect Hyb 3 Not applicable. SureSelect Block 2 Not applicable. SureSelect Indexing Block 1 Not applicable. SureSelect Indexing Block 3 Not applicable. SureSelect ILM Index Pre Not applicable. Capture PCR Reverse Primer

Response

10X End Repair Buffer Not applicable. 5X T4 DNA Ligase Buffer Not applicable. Klenow DNA Polymerase Not applicable. T4 DNA Ligase Not applicable. T4 DNA Polymerase Not applicable. T4 Polynucleotide Kinase Not applicable. dNTP Mix Not applicable. 10X Klenow Polymerase Not applicable. Buffer Exo(-) Klenow Not applicable. dATP Not applicable. SureSelect Adaptor Oligo Mix Not applicable. SureSelect Primer Not applicable. PCR Primer Index 1 Not applicable. PCR Primer Index 2 Not applicable. PCR Primer Index 3 Not applicable. PCR Primer Index 4 Not applicable. PCR Primer Index 5 Not applicable. PCR Primer Index 6 Not applicable. PCR Primer Index 7 Not applicable. PCR Primer Index 8 Not applicable. PCR Primer Index 9 Not applicable. PCR Primer Index 10 Not applicable. PCR Primer Index 11 Not applicable. PCR Primer Index 12 Not applicable. PCR Primer Index 13 Not applicable. PCR Primer Index 14 Not applicable. PCR Primer Index 15 Not applicable. PCR Primer Index 16 Not applicable. SureSelect Hyb 1 P305 + P351 + P338 - IF IN EYES: Rinse cautiously Date of issue/ Date of : 31/03/2016 Date of issue/ Date of : 27/02/2014. Version : 3 7/120 with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337 + P313 - If eye irritation persists: Get medical attention. SureSelect Hyb 2 Not applicable. SureSelect Hyb 4 Not applicable. SureSelect Binding Buffer Not applicable. SureSelect Wash Buffer 1 Not applicable. SureSelect Wash Buffer 2 Not applicable. SureSelect Elution Buffer P304 + P340 + P310 - IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or physician. P301 + P310 + P330 + P331 - IF SWALLOWED: Immediately call a POISON CENTER or physician. Rinse mouth. Do NOT induce vomiting. P303 + P361 + P353 + P363 + P310 - IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower. Wash contaminated clothing before reuse. Immediately call a POISON CENTER or physician. P305 + P351 + P338 + P310 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or physician. SureSelect Neutralization P302 + P352 + P362-2 + P363 - IF ON SKIN: Wash Buffer with plenty of soap and water. Take off contaminated clothing. Wash contaminated clothing before reuse. P332 + P313 - If skin irritation occurs: Get medical attention. P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337 + P313 - If eye irritation persists: Get medical attention. SureSelect RNase Block Not applicable. SureSelect ILM Indexing Not applicable. Post Capture Forward PCR Primer SureSelect Hyb 3 Not applicable. SureSelect Block 2 Not applicable. SureSelect Indexing Block 1 Not applicable. SureSelect Indexing Block 3 Not applicable. SureSelect ILM Index Pre Not applicable. Capture PCR Reverse Primer

Storage

10X End Repair Buffer Not applicable. 5X T4 DNA Ligase Buffer Not applicable. Klenow DNA Polymerase Not applicable. T4 DNA Ligase Not applicable. T4 DNA Polymerase Not applicable. T4 Polynucleotide Kinase Not applicable. dNTP Mix Not applicable. 10X Klenow Polymerase Not applicable. Buffer Exo(-) Klenow Not applicable. dATP Not applicable. SureSelect Adaptor Oligo Mix Not applicable. SureSelect Primer Not applicable. PCR Primer Index 1 Not applicable. PCR Primer Index 2 Not applicable. PCR Primer Index 3 Not applicable. Date of issue/ Date of : 31/03/2016 Date of issue/ Date of : 27/02/2014. Version : 3 8/120 PCR Primer Index 4 Not applicable. PCR Primer Index 5 Not applicable. PCR Primer Index 6 Not applicable. PCR Primer Index 7 Not applicable. PCR Primer Index 8 Not applicable. PCR Primer Index 9 Not applicable. PCR Primer Index 10 Not applicable. PCR Primer Index 11 Not applicable. PCR Primer Index 12 Not applicable. PCR Primer Index 13 Not applicable. PCR Primer Index 14 Not applicable. PCR Primer Index 15 Not applicable. PCR Primer Index 16 Not applicable. SureSelect Hyb 1 Not applicable. SureSelect Hyb 2 Not applicable. SureSelect Hyb 4 Not applicable. SureSelect Binding Buffer Not applicable. SureSelect Wash Buffer 1 Not applicable. SureSelect Wash Buffer 2 Not applicable. SureSelect Elution Buffer P405 - Store locked up. SureSelect Neutralization Not applicable. Buffer SureSelect RNase Block Not applicable. SureSelect ILM Indexing Not applicable. Post Capture Forward PCR Primer SureSelect Hyb 3 Not applicable. SureSelect Block 2 Not applicable. SureSelect Indexing Block 1 Not applicable. SureSelect Indexing Block 3 Not applicable. SureSelect ILM Index Pre Not applicable. Capture PCR Reverse Primer

Disposal

10X End Repair Buffer Not applicable. 5X T4 DNA Ligase Buffer Not applicable. Klenow DNA Polymerase Not applicable. T4 DNA Ligase Not applicable. T4 DNA Polymerase Not applicable. T4 Polynucleotide Kinase Not applicable. dNTP Mix Not applicable. 10X Klenow Polymerase Not applicable. Buffer Exo(-) Klenow Not applicable. dATP Not applicable. SureSelect Adaptor Oligo Mix Not applicable. SureSelect Primer Not applicable. PCR Primer Index 1 Not applicable. PCR Primer Index 2 Not applicable. PCR Primer Index 3 Not applicable. PCR Primer Index 4 Not applicable. PCR Primer Index 5 Not applicable. PCR Primer Index 6 Not applicable. PCR Primer Index 7 Not applicable. PCR Primer Index 8 Not applicable. PCR Primer Index 9 Not applicable. PCR Primer Index 10 Not applicable. PCR Primer Index 11 Not applicable. PCR Primer Index 12 Not applicable. PCR Primer Index 13 Not applicable. PCR Primer Index 14 Not applicable. PCR Primer Index 15 Not applicable. PCR Primer Index 16 Not applicable. SureSelect Hyb 1 Not applicable. Date of issue/ Date of : 31/03/2016 Date of issue/ Date of : 27/02/2014. Version : 3 9/120 SureSelect Hyb 2 Not applicable. SureSelect Hyb 4 P501 - Dispose of contents and container in accordance with all local, regional, national and international regulations. SureSelect Binding Buffer Not applicable. SureSelect Wash Buffer 1 Not applicable. SureSelect Wash Buffer 2 Not applicable. SureSelect Elution Buffer P501 - Dispose of contents and container in accordance with all local, regional, national and international regulations. SureSelect Neutralization Not applicable. Buffer SureSelect RNase Block Not applicable. SureSelect ILM Indexing Not applicable. Post Capture Forward PCR Primer SureSelect Hyb 3 Not applicable. SureSelect Block 2 Not applicable. SureSelect Indexing Block 1 Not applicable. SureSelect Indexing Block 3 Not applicable. SureSelect ILM Index Pre Not applicable. Capture PCR Reverse Primer

Supplemental label elements

10X End Repair Buffer Not applicable. elements 5X T4 DNA Ligase Buffer Not applicable. Klenow DNA Polymerase Not applicable. T4 DNA Ligase Not applicable. T4 DNA Polymerase Not applicable. T4 Polynucleotide Kinase Not applicable. dNTP Mix Not applicable. 10X Klenow Polymerase Not applicable. Buffer Exo(-) Klenow Not applicable. dATP Not applicable. SureSelect Adaptor Oligo Mix Not applicable. SureSelect Primer Not applicable. PCR Primer Index 1 Not applicable. PCR Primer Index 2 Not applicable. PCR Primer Index 3 Not applicable. PCR Primer Index 4 Not applicable. PCR Primer Index 5 Not applicable. PCR Primer Index 6 Not applicable. PCR Primer Index 7 Not applicable. PCR Primer Index 8 Not applicable. PCR Primer Index 9 Not applicable. PCR Primer Index 10 Not applicable. PCR Primer Index 11 Not applicable. PCR Primer Index 12 Not applicable. PCR Primer Index 13 Not applicable. PCR Primer Index 14 Not applicable. PCR Primer Index 15 Not applicable. PCR Primer Index 16 Not applicable. SureSelect Hyb 1 Not applicable. SureSelect Hyb 2 Not applicable. SureSelect Hyb 4 Not applicable. SureSelect Binding Buffer Not applicable. SureSelect Wash Buffer 1 Not applicable. SureSelect Wash Buffer 2 Not applicable. SureSelect Elution Buffer Not applicable. SureSelect Neutralization Not applicable. Buffer SureSelect RNase Block Not applicable. Date of issue/ Date of : 31/03/2016 Date of issue/ Date of : 27/02/2014. Version : 3 10/120 SureSelect ILM Indexing Not applicable. Post Capture Forward PCR Primer SureSelect Hyb 3 Not applicable. SureSelect Block 2 Not applicable. SureSelect Indexing Block 1 Not applicable. SureSelect Indexing Block 3 Not applicable. SureSelect ILM Index Pre Not applicable. Capture PCR Reverse Primer Other hazards which do not : 10X End Repair Buffer None known. result in classification 5X T4 DNA Ligase Buffer None known. Klenow DNA Polymerase None known. T4 DNA Ligase None known. T4 DNA Polymerase None known. T4 Polynucleotide Kinase None known. dNTP Mix None known. 10X Klenow Polymerase None known. Buffer Exo(-) Klenow None known. dATP None known. SureSelect Adaptor Oligo Mix None known. SureSelect Primer None known. PCR Primer Index 1 None known. PCR Primer Index 2 None known. PCR Primer Index 3 None known. PCR Primer Index 4 None known. PCR Primer Index 5 None known. PCR Primer Index 6 None known. PCR Primer Index 7 None known. PCR Primer Index 8 None known. PCR Primer Index 9 None known. PCR Primer Index 10 None known. PCR Primer Index 11 None known. PCR Primer Index 12 None known. PCR Primer Index 13 None known. PCR Primer Index 14 None known. PCR Primer Index 15 None known. PCR Primer Index 16 None known. SureSelect Hyb 1 None known. SureSelect Hyb 2 None known. SureSelect Hyb 4 None known. SureSelect Binding Buffer None known. SureSelect Wash Buffer 1 None known. SureSelect Wash Buffer 2 None known. SureSelect Elution Buffer Causes digestive tract burns. SureSelect Neutralization None known. Buffer SureSelect RNase Block None known. SureSelect ILM Indexing None known. Post Capture Forward PCR Primer SureSelect Hyb 3 None known. SureSelect Block 2 None known. SureSelect Indexing Block 1 None known. SureSelect Indexing Block 3 None known. SureSelect ILM Index Pre None known. Capture PCR Reverse Primer Date of issue/ Date of : 31/03/2016 Date of issue/ Date of : 27/02/2014. Version : 3 11/120