RNA Isolation Kit, Part Number 200345

Hazard statements (CLP)

H225, H227, H301, H301+H311+H331, H302, H302+H332, H310, H310+H330, H311, H314, H315, H317, H318, H319, H330, H331, H332, H335, H336, H341, H351, H361, H372, H373, H411, H412

Code

Statements

H225

Highly Flammable liquid and vapour

2.1 Classification of the substance or mixture

ß-Mercaptoethanol H227 FLAMMABLE LIQUIDS - Category 4 H301 ACUTE TOXICITY (oral) - Category 3 H310 ACUTE TOXICITY (dermal) - Category 2 H330 ACUTE TOXICITY (inhalation) - Category 2 H315 SKIN CORROSION/IRRITATION - Category 2 H318 SERIOUS EYE DAMAGE/EYE IRRITATION - Category 1 H317 SKIN SENSITISATION - Category 1 H335 SPECIFIC TARGET ORGAN TOXICITY - SINGLE EXPOSURE (Respiratory tract irritation) - Category 3 H411 LONG-TERM (CHRONIC) AQUATIC HAZARD - Category 2 Isopropanol H225 FLAMMABLE LIQUIDS - Category 2 H319 SERIOUS EYE DAMAGE/EYE IRRITATION - Category 2A H336 SPECIFIC TARGET ORGAN TOXICITY - SINGLE EXPOSURE (Narcotic effects) - Category 3 Denaturing solution H302 ACUTE TOXICITY (oral) - Category 4 H332 ACUTE TOXICITY (inhalation) - Category 4 H412 LONG-TERM (CHRONIC) AQUATIC HAZARD - Category 3 2M Sodium Acetate H315 SKIN CORROSION/IRRITATION - Category 2 H319 SERIOUS EYE DAMAGE/EYE IRRITATION - Category 2A RNA Phenol pH 5.3 - 5.7 Equilibrated with Succinic Acid H227 FLAMMABLE LIQUIDS - Category 4 H301 ACUTE TOXICITY (oral) - Category 3 H311 ACUTE TOXICITY (dermal) - Category 3 H331 ACUTE TOXICITY (inhalation) - Category 3 H314 SKIN CORROSION/IRRITATION - Category 1B H318 SERIOUS EYE DAMAGE/EYE IRRITATION - Category 1 H341 GERM CELL MUTAGENICITY - Category 2 H373 SPECIFIC TARGET ORGAN TOXICITY - REPEATED EXPOSURE - Category 2 RNA Isolation Chloroform, Isoamyl Alcohol H302 ACUTE TOXICITY (oral) - Category 4 H331 ACUTE TOXICITY (inhalation) - Category 3 H315 SKIN CORROSION/IRRITATION - Category 2 H319 SERIOUS EYE DAMAGE/EYE IRRITATION - Category 2A H351 CARCINOGENICITY - Category 2 H361 REPRODUCTIVE TOXICITY (Unborn child) - Category 2 H372 SPECIFIC TARGET ORGAN TOXICITY - REPEATED EXPOSURE - Category 1 2M Sodium Acetate Percentage of the mixture consisting of ingredient(s) of unknown dermal toxicity: 10 - 30% Percentage of the mixture consisting of ingredient(s) of unknown inhalation toxicity: 10 - 30% RNA Phenol pH 5.3 - 5.7 Percentage of the mixture consisting of ingredient(s) Equilibrated with Succinic of unknown dermal toxicity: 1 - 10% Acid Percentage of the mixture consisting of ingredient(s) of unknown inhalation toxicity: 1 - 10% RNA Isolation Chloroform, Percentage of the mixture consisting of ingredient(s) Isoamyl Alcohol of unknown dermal toxicity: 1 - 10% RNA Isolation Chloroform, Percentage of the mixture consisting of ingredient(s) Isoamyl Alcohol of unknown hazards to the aquatic environment: 2%

Hazard pictograms

ß-Mercaptoethanol Isopropanol Denaturing solution 2M Sodium Acetate RNA Phenol pH 5.3 - 5.7 Equilibrated with Succinic Acid RNA Isolation Chloroform, Isoamyl Alcohol

Signal word

ß-Mercaptoethanol DANGER Isopropanol DANGER Denaturing solution WARNING 2M Sodium Acetate WARNING RNA Phenol pH 5.3 - 5.7 DANGER Equilibrated with Succinic Acid RNA Isolation Chloroform, DANGER Isoamyl Alcohol

Hazard statements

ß-Mercaptoethanol H227 - Combustible liquid. H310 + H330 - Fatal in contact with skin or if inhaled. H301 - Toxic if swallowed. H318 - Causes serious eye damage. H315 - Causes skin irritation. H317 - May cause an allergic skin reaction. H335 - May cause respiratory irritation. H411 - Toxic to aquatic life with long lasting effects. Isopropanol H225 - Highly flammable liquid and vapour. H319 - Causes serious eye irritation. H336 - May cause drowsiness or dizziness. Denaturing solution H302 + H332 - Harmful if swallowed or if inhaled. H412 - Harmful to aquatic life with long lasting effects. 2M Sodium Acetate H319 - Causes serious eye irritation. H315 - Causes skin irritation. RNA Phenol pH 5.3 - 5.7 H227 - Combustible liquid. Equilibrated with Succinic Acid H301 + H311 + H331 - Toxic if swallowed, in contact with skin or if inhaled. H314 - Causes severe skin burns and eye damage. H341 - Suspected of causing genetic defects. H373 - May cause damage to organs through prolonged or repeated exposure. RNA Isolation Chloroform, H331 - Toxic if inhaled. Isoamyl Alcohol H302 - Harmful if swallowed. H319 - Causes serious eye irritation. H315 - Causes skin irritation. H361 - Suspected of damaging the unborn child. H351 - Suspected of causing cancer. H372 - Causes damage to organs through prolonged or repeated exposure.

Prevention

ß-Mercaptoethanol P280 - Wear protective gloves. Wear eye or face protection. P284 - Wear respiratory protection. P210 - Keep away from flames and hot surfaces. - No smoking. P271 - Use only outdoors or in a well-ventilated area. P273 - Avoid release to the environment. P262 - Do not get in eyes, on skin, or on clothing. P260 - Do not breathe vapour. P270 - Do not eat, drink or smoke when using this product. P264 - Wash hands thoroughly after handling. P272 - Contaminated work clothing should not be allowed out of the workplace. Isopropanol P280 - Wear protective gloves. Wear eye or face protection. P210 - Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P241 - Use explosion-proof electrical, ventilating, lighting and all material-handling equipment. P242 - Use only non-sparking tools. P243 - Take precautionary measures against static discharge. P233 - Keep container tightly closed. P271 - Use only outdoors or in a well-ventilated area. P261 - Avoid breathing vapour. P264 - Wash hands thoroughly after handling. Denaturing solution P271 - Use only outdoors or in a well-ventilated area. P273 - Avoid release to the environment. P261 - Avoid breathing vapour. P270 - Do not eat, drink or smoke when using this product. P264 - Wash hands thoroughly after handling. 2M Sodium Acetate P280 - Wear protective gloves. Wear eye or face protection. P264 - Wash hands thoroughly after handling. RNA Phenol pH 5.3 - 5.7 P201 - Obtain special instructions before use. Equilibrated with Succinic Acid P202 - Do not handle until all safety precautions have been read and understood. P281 - Use personal protective equipment as required. P280 - Wear protective gloves. Wear eye or face protection. Wear protective clothing. P210 - Keep away from flames and hot surfaces. - No smoking. P271 - Use only outdoors or in a well-ventilated area. P260 - Do not breathe vapour. P270 - Do not eat, drink or smoke when using this product. P264 - Wash hands thoroughly after handling. RNA Isolation Chloroform, P201 - Obtain special instructions before use. Isoamyl Alcohol P202 - Do not handle until all safety precautions have been read and understood. P281 - Use personal protective equipment as required. P280 - Wear protective gloves. Wear eye or face protection. P271 - Use only outdoors or in a well-ventilated area. P260 - Do not breathe vapour. P270 - Do not eat, drink or smoke when using this product. P264 - Wash hands thoroughly after handling.

Response

ß-Mercaptoethanol P391 - Collect spillage. P304 + P340 + P310 - IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or physician. P301 + P310 + P330 - IF SWALLOWED: Immediately call a POISON CENTER or physician. Rinse mouth. P302 + P361 + P350 + P310 + P362 + P363 - IF ON SKIN: Take off immediately all contaminated clothing. Gently wash with plenty of soap and water. Immediately call a POISON CENTER or physician. Take off contaminated clothing. Wash contaminated clothing before reuse. P333 + P313 - If skin irritation or rash occurs: Get medical attention. P305 + P351 + P338 + P310 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or physician. Isopropanol P304 + P340 + P312 - IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. Call a POISON CENTER or physician if you feel unwell. P303 + P361 + P353 - IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower. P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337 + P313 - If eye irritation persists: Get medical attention. Denaturing solution P304 + P340 + P312 - IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. Call a POISON CENTER or physician if you feel unwell. P301 + P312 + P330 - IF SWALLOWED: Call a POISON CENTER or physician if you feel unwell. Rinse mouth. 2M Sodium Acetate P302 + P352 + P362 + P363 - IF ON SKIN: Wash with plenty of soap and water. Take off contaminated clothing. Wash contaminated clothing before reuse. P332 + P313 - If skin irritation occurs: Get medical attention. P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337 + P313 - If eye irritation persists: Get medical attention. RNA Phenol pH 5.3 - 5.7 P314 - Get medical attention if you feel unwell. Equilibrated with Succinic Acid P308 + P313 - IF exposed or concerned: Get medical attention. P304 + P340 + P310 - IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or physician. P301 + P310 + P330 + P331 - IF SWALLOWED: Immediately call a POISON CENTER or physician. Rinse mouth. Do NOT induce vomiting. P303 + P361 + P353 + P363 + P310 - IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower. Wash contaminated clothing before reuse. Immediately call a POISON CENTER or physician. P302 + P352 + P312 - IF ON SKIN: Wash with plenty of soap and water. Call a POISON CENTER or physician if you feel unwell. P305 + P351 + P338 + P310 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or physician. RNA Isolation Chloroform, P314 - Get medical attention if you feel unwell. Isoamyl Alcohol P308 + P313 - IF exposed or concerned: Get medical attention. P304 + P340 + P311 - IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. Call a POISON CENTER or physician. P301 + P312 + P330 - IF SWALLOWED: Call a POISON CENTER or physician if you feel unwell. Rinse mouth. P302 + P352 + P362 + P363 - IF ON SKIN: Wash with plenty of soap and water. Take off contaminated clothing. Wash contaminated clothing before reuse. P332 + P313 - If skin irritation occurs: Get medical attention. P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337 + P313 - If eye irritation persists: Get medical attention.

Storage

ß-Mercaptoethanol P405 - Store locked up. P403 - Store in a well-ventilated place. P235 - Keep cool. Isopropanol P405 - Store locked up. P403 - Store in a well-ventilated place. P235 - Keep cool. Denaturing solution Not applicable. 2M Sodium Acetate Not applicable. RNA Phenol pH 5.3 - 5.7 P405 - Store locked up. Equilibrated with Succinic Acid P403 - Store in a well-ventilated place. P235 - Keep cool. RNA Isolation Chloroform, P405 - Store locked up. Isoamyl Alcohol

Disposal

ß-Mercaptoethanol P501 - Dispose of contents and container in accordance with all local, regional, national and international regulations. Isopropanol P501 - Dispose of contents and container in accordance with all local, regional, national and international regulations. Denaturing solution P501 - Dispose of contents and container in accordance with all local, regional, national and international regulations. 2M Sodium Acetate Not applicable. RNA Phenol pH 5.3 - 5.7 P501 - Dispose of contents and container in Equilibrated with Succinic accordance with all local, regional, national and Acid international regulations. RNA Isolation Chloroform, P501 - Dispose of contents and container in Isoamyl Alcohol accordance with all local, regional, national and international regulations.

Supplemental label elements

elements Additional warning : ß-Mercaptoethanol Not applicable. phrases Isopropanol Not applicable. Denaturing solution Not applicable. 2M Sodium Acetate Not applicable. RNA Phenol pH 5.3 - 5.7 Not applicable. Equilibrated with Succinic Acid RNA Isolation Chloroform, Not applicable. Isoamyl Alcohol Other hazards which do not : ß-Mercaptoethanol None known. result in classification Isopropanol None known. Denaturing solution None known. 2M Sodium Acetate None known. RNA Phenol pH 5.3 - 5.7 Causes digestive tract burns. Equilibrated with Succinic Acid RNA Isolation Chloroform, None known. Isoamyl Alcohol